the goodman group
university of cambridge  

   Department Publications

Linear Aliphatic Dialkynes as Alternative Linkers for Double-Click Stapling of p53-Derived Peptides

Yu Heng Lau, Dr Peterson de Andrade, Dr Grahame J McKenzie, Prof Ashok R Venkitaraman and Prof David R Spring
ChemBioChem DOI: 10.1002/cbic.201402374

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

Steffen Glockner, Duc N Tran, Richard Ingham, Sabine Fenner, Zoe E Wilson, Claudio Battilocchio, Steven V Ley
Organic and Biomolecular Chemistry DOI: 10.1039/C4OB02105C

Pyrene-Edged FeII4L6 Cages Adaptively Reconfigure During Guest Binding

Tanya K Ronson, Aaron B League, Laura Gagliardi, Christopher J Cramer, and Jonathan R Nitschke
Journal of the American Chemical Society DOI: 10.1021/ja507617h

Reversible Interconversion of CO2 and Formate by a Molybdenum-Containing Formate Dehydrogenase

Arnau Bassegoda, Christopher Madden, David W Wakerley, Erwin Reisner, and Judy Hirst
Journal of the American Chemical Society DOI: 10.1021/ja508647u

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

Xiaoyu Yang, Tao Wu, Robert J Phipps, and F Dean Toste
Chemical Reviews DOI: 10.1021/cr500277b

Solid-state photoreactivity of 9-substituted acridizinium bromide salts

Samuel A Stratford, Mihails Arhangelskis, Dejan-Kresimir Bucar, William Jones
CrystEngComm DOI: 10.1039/C4CE01622J

Binding Hotspots of BAZ2B Bromodomain: Histone Interaction Revealed by Solution NMR Driven Docking

Fleur M Ferguson, David M Dias, João P G L M Rodrigues, Hans Wienk, Rolf Boelens, Alexandre M J J Bonvin, Chris Abell, and Alessio Ciulli
Biochemistry DOI: 10.1021/bi500909d

Shallow-tunnelling correction factor for use with Wigner-Eyring transition-state theory

Yanchuan Zhang, Judith B Rommel, Marko T Cvitas, Stuart C Althorpe
PCCP DOI: 10.1039/C4CP03235G

Optimizing the Selectivity of Surface-Adsorbing Multivalent Polymers

Nicholas B Tito and Daan Frenkel
Macromolecules DOI: 10.1021/ma5014918

Polypharmacology Modelling Using Proteochemometrics (PCM): Recent Methodological Developments, Applications to Target Families, and Future Prospects

Isidro Cortes-Ciriano, Qurrat ul Ain, Vigneshwari Subramanian, Bart Lenselink, Oscar Mendez-Lucio, AP IJzerman, Gerd Wohlfahrt, Peteris Prusis, Therese E Malliavin, Gerard van Westen, Andreas Bender
MedChemComm DOI: 10.1039/C4MD00216D


Kristina A Ganzinger, Dr Priyanka Narayan, Dr Seema S Qamar, Dr Laura Weimann, Dr Rohan T Ranasinghe, Prof Adriano Aguzzi, Prof Christopher M Dobson, Dr James McColl, Dr Peter St George-Hyslop and Prof David Klenerman
ChemBioChem DOI: 10.1002/cbic.201402377

Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

Hai-Jie Tong, Clare Fitzgerald, Peter J Gallimore, Markus Kalberer, Marina Konstantinovna Kuimova, Peter C Seville, Andrew D Ward, Francis D Pope
Chemical Communications DOI: 10.1039/C4CC05803H

Gram-Scale Enantioselective Formal Synthesis of Morphine through an ortho – para Oxidative Phenolic Coupling Strategy

Dr Matthieu Tissot, Dr Robert J Phipps, Dr Catherine Lucas, Dr Rafael M Leon, Dr Robert D M Pace, Dr Tifelle Ngouansavanh and Prof Matthew J Gaunt
Angewandte Chemie International Edition DOI: 10.1002/anie.201408435

Solvent Effects upon Guest Binding and Dynamics of a FeII4L4 Cage

Jeanne L Bolliger, Tanya K Ronson, Masahiro Ogawa, and Jonathan R Nitschke
Journal of the American Chemical Society DOI: 10.1021/ja5077102

Applications of dynamic combinatorial chemistry for the determination of effective molarity

Maria Ciaccia, Irene Tosi, Laura Baldini, Roberta Cacciapaglia, Luigi Mandolini, Stefano Di Stefano, Christopher A Hunter
Chemical Science DOI: 10.1039/C4SC02347A

Targeting DNA G-Quadruplexes with Helical Small Molecules

Dr Sebastian Müller, Dr Katta Laxmi-Reddy, Dr Prakrit V Jena, Dr Benoit Baptiste, Dr Zeyuan Dong, Dr Frédéric Godde, Prof Taekjip Ha, Dr Raphaël Rodriguez, Prof Shankar Balasubramanian and Dr Ivan Huc
ChemBioChem DOI: 10.1002/cbic.201402439

Diversity-Oriented Synthesis of Drug-Like Macrocyclic Scaffolds Using an Orthogonal Organo- and Metal Catalysis Strategy

Dr André Grossmann, Sean Bartlett, Matej Janecek, Dr James T Hodgkinson and Prof David R Spring
Angewandte Chemie International Edition DOI: 10.1002/anie.201406865

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck-Suzuki reaction

Esther Alza, Luca Laraia, Brett M Ibbeson, Suil Collins, Warren R J D Galloway, Jamie E Stokes, Ashok R Venkitaraman, David R Spring
Chemical Science DOI: 10.1039/C4SC02547D

Design and Application of a Low-Temperature Continuous Flow Chemistry Platform

James A Newby, D Wayne Blaylock, Paul M Witt, Julio C Pastre, Marija K Zacharova, Steven V Ley, and Duncan L Browne
Organic Process Research and Development DOI: 10.1021/op500213j

Design and Structural Analysis of Aromatic Inhibitors of Type II Dehydroquinase from Mycobacterium tuberculosis

Dr Nigel I Howard, Dr Marcio V B Dias, Dr Fabienne Peyrot, Dr Liuhong Chen, Dr Marco F Schmidt, Prof Tom L Blundell and Prof Chris Abell
ChemMedChem DOI: 10.1002/cmdc.201402298

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department of chemistry University of Cambridge