Department of Chemistry

Christopher M Dobson FRS Publications (2008)


Self-templated nucleation in peptide and protein aggregation.
Auer S, Dobson CM, Vendruscolo M, Maritan A
Phys Rev Lett, 2008, 25, 258101-.


A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates.
Auer S, Meersman F, Dobson CM, Vendruscolo M
PLoS Comput Biol, 2008-11, 11, e1000222-. DOI: 10.1371/journal.pcbi.1000222


Recombinant amyloid beta-peptide production by coexpression with an affibody ligand
Macao B, Hoyer W, Sandberg A, Brorsson AC, Dobson CM, Hard T
BMC BIOTECHNOL, 2008, -. DOI: 10.1186/1472-6750-8-82


Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Chan PH, Pardon E, Menzer L, De Genst E, Kumita JR, Christodoulou J, Saerens D, Brans A, Bouillenne F, Archer DB, Robinson CV, Muyldermans S, Matagne A, Redfield C, Wyns L, Dobson CM, Dumoulin M
Biochemistry, 2008, 42, 11041-11054. DOI: 10.1021/bi8005797


Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation.
Calloni G, Lendel C, Campioni S, Giannini S, Gliozzi A, Relini A, Vendruscolo M, Dobson CM, Salvatella X, Chiti F
J Am Chem Soc, 2008, 39, 13040-13050. DOI: 10.1021/ja8029224


Immunological features of alpha-synuclein in Parkinson's disease.
Roodveldt C, Christodoulou J, Dobson CM
J Cell Mol Med, 2008-10, 5B, 1820-1829. DOI: 10.1111/j.1582-4934.2008.00450.x


Label-free detection of amyloid growth with microcantilever sensors
Knowles TPJ, Shu W, Huber F, Lang HP, Gerber C, Dobson CM, Welland ME
NANOTECHNOLOGY, 2008, 38, -. DOI: 10.1088/0957-4484/19/38/384007


Direct characterization of amyloidogenic oligomers by single-molecule fluorescence.
Orte A, Birkett NR, Clarke RW, Devlin GL, Dobson CM, Klenerman D
Proc Natl Acad Sci U S A, 2008, 38, 14424-14429. DOI: 10.1073/pnas.0803086105


Direct characterization of amyloidogenic oligomers by single-molecule fluorescence
Orte A, Birkett NR, Clarke RW, Devlin GL, Dobson CM, Klenerman D
P NATL ACAD SCI USA, 2008, 38, 14424-14429. DOI: 10.1073/pnas.0803086105


BIOT 336-Exploring the energy landscape of human lysozyme toward an elucidation of the molecular mechanism of systemic amyloidosis
Dhulesia A, Kumita JR, Nietlispach D, Salvatella X, Dobson CM
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, -.


PHYS 90-Life on the edge: The origins and proliferation of protein misfolding diseases
Dobson CM
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, -.


BIOT 243-Biophysical study of the aggregation of human lysozyme into amyloid fibrils
Dhulesia A, Baldwin AJ, Mossuto MF, Salvatella X, Dobson CM
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, -.


Characterizing the first steps of amyloid formation for the ccbeta peptide.
Strodel B, Fitzpatrick AW, Vendruscolo M, Dobson CM, Wales DJ
J Phys Chem B, 2008, 32, 9998-10004. DOI: 10.1021/jp801222x


Life on the edge: The nature and origins of protein misfolding diseases
Dobson CM
J PEPT SCI, 2008-08, 8, 26-26.


Prediction of aggregation-prone regions in structured proteins.
Tartaglia GG, Pawar AP, Campioni S, Dobson CM, Chiti F, Vendruscolo M
J Mol Biol, 2008, 2, 425-436. DOI: 10.1016/j.jmb.2008.05.013


Life on the edge: the origins and proliferation of protein misfolding diseases
Dobson CM
FEBS JOURNAL, 2008-06, 27-27.


Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.
Rivers RC, Kumita JR, Tartaglia GG, Dedmon MM, Pawar A, Vendruscolo M, Dobson CM, Christodoulou J
Protein Sci, 2008-05, 5, 887-898. DOI: 10.1110/ps.073181508


A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.
Gsponer J, Christodoulou J, Cavalli A, Bui JM, Richter B, Dobson CM, Vendruscolo M
Structure, 2008-05, 5, 736-746. DOI: 10.1016/j.str.2008.02.017


Functionalised amyloid fibrils for roles in cell adhesion
Gras SL, Tickler AK, Squires AM, Devlin GL, Horton MA, Dobson CM, MacPhee CE
BIOMATERIALS, 2008-04, 11, 1553-1562. DOI: 10.1016/j.biomaterials.2007.11.028


Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses.
Várnai P, Dobson CM, Vendruscolo M
J Mol Biol, 2008, 2, 575-588. DOI: 10.1016/j.jmb.2008.01.012


Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins
Dalal S, Canet D, Kaiser SE, Dobson CM, Regan L
PROTEIN ENG DES SEL, 2008-03, 3, 197-206. DOI: 10.1093/protein/gzm088


Characterization of folding the four-helix bundle protein Rop by real-time NMR
van Nuland NAJ, Dobson CM, Regan L
PROTEIN ENG DES SEL, 2008-03, 3, 165-170. DOI: 10.1093/protein/gzm081


Protein misfolding and disease: from the test tube to the organism.
Luheshi LM, Crowther DC, Dobson CM
Curr Opin Chem Biol, 2008-02, 1, 25-31. DOI: 10.1016/j.cbpa.2008.02.011


Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements
Baldwin AJ, Anthony-Cahill SJ, Knowles TPJ, Lippens G, Christodoulou J, Barker PD, Dobson CM
ANGEW CHEM INT EDIT, 2008, 18, 3385-3387. DOI: 10.1002/anie.200703915


"“Protein Folding and Misfolding: From Atoms to Organisms"" in Physical biology: From Atoms to Medicine"
Dobson CM
, 2008, 289-335.


Calculation of the free energy barriers in the oligomerisation of Abeta peptide fragments.
Cheon M, Favrin G, Chang I, Dobson CM, Vendruscolo M
Front Biosci, 2008, 5614-5622.