Department of Chemistry

Synthesis Publications (2009)

Visible light-driven H(2) production by hydrogenases attached to dye-sensitized TiO(2) nanoparticles.
Reisner E, Powell DJ, Cavazza C, Fontecilla-Camps JC, Armstrong FA
J Am Chem Soc 2009, 131, 18457-18466. DOI: 10.1021/ja907923r

Functional and Tuneable Amino Acid Polymers Prepared by RAFT Polymerization
Evans AC, Skey J, Wright M, Qu WJ, Ondeck C, Longbottom DA, O'Reilly RK
J POLYM SCI POL CHEM 2009, 47, 6814-6826. DOI: 10.1002/pola.23721

3D small-molecule microarrays.
Marsden DM, Nicholson RL, Ladlow M, Spring DR
Equipment Design, Hydrogel, Materials Testing, Methods, Polyethylene Glycols, Protein Array Analysis 2009, 8, 7107-7109. DOI: 10.1039/b913665g

Systems chemistry: Molecular networks come of age.
Nitschke JR
Biogenesis, Chemistry, Drug Interactions, Evolution, Chemical, Kinetics, Systems Theory, Thermodynamics 2009, 18, 736-738. DOI: 10.1038/462736a

Predicting inclusion behaviour and framework structures in organic crystals.
Cruz-Cabeza AJ, Day GM, Jones W
Chemistry 2009, 15, 13033-13040. DOI: 10.1002/chem.200901703

Confined palladium colloids in mesoporous frameworks for carbon nanotube growth
Berenguer-Murcia A, Rebrov EV, Cabaj M, Wheatley AEH, Johnson BFG, Robertson J, Schouten JC
JOURNAL OF MATERIALS SCIENCE 2009, 44, 6563-6570. DOI: 10.1007/s10853-009-3629-y

Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.
Ashbridge B, Orte A, Yeoman JA, Kirwan M, Vulliamy T, Dokal I, Klenerman D, Balasubramanian S
Amino Acid Substitution, Binding Sites, Cell Cycle Proteins, Cell Line, DNA Restriction Enzymes, Dyskeratosis Congenita, Humans, Microscopy, Confocal, Mutation, Nuclear Proteins, Point Mutation, Protein Binding, RNA, Recombinant Fusion Proteins, Signal Processing, Computer-Assisted, Spectrometry, Fluorescence, Telomerase, Transfection 2009, 5, 10858-10865. DOI: 10.1021/bi901373e

A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.
Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A
Adenosine, Combinatorial Chemistry Techniques, Crystallography, X-Ray, Disulfides, Drug Design, Molecular Sequence Data, Molecular Structure, Mycobacterium tuberculosis, Peptide Synthases, Protein Conformation, Thionucleosides 2009, 11, 2772-2779. DOI: 10.1002/cbic.200900537

The regioselective photochemical rearrangement of alpha-[PN(t)Bu](4).
Bladt H, Gonzalez Calera S, Goodman JM, Less RJ, Naseri V, Steiner A, Wright DS
2009, 0, 6637-6639. DOI: 10.1039/b914370j

Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.
Carter CF, Baxendale IR, O'Brien M, Pavey JB, Ley SV
Org Biomol Chem 2009, 7, 4594-4597. DOI: 10.1039/b917289k

Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxidation: Applications in the Total Synthesis of Ellagitannin Natural Products
Su XB, Thomas GL, Galloway WRJD, Surry DS, Spandl RJ, Spring DR
cuprates, total synthesis, ring-closing, natural products, biaryls, INTRAMOLECULAR COUPLING REACTIONS, DIVERSITY-ORIENTED SYNTHESIS, CHEMICAL-SYNTHESIS, VINYL HALIDES, SANGUIIN H-5, CHEMISTRY, ARYL, HYDROGENATION, ELAEOCARPUSIN, IODINATION 2009, 11, 3880-3896. DOI: 10.1055/s-0029-1218154

Amplifying Different [2]Catenanes in an Aqueous Donor-Acceptor Dynamic Combinatorial Library
Au-Yeung HY, Pantos GD, Sanders JKM
J AM CHEM SOC 2009, 131, 16030-+. DOI: 10.1021/ja906634h

THREE-COMPONENT MOLECULAR ASSEMBLY USING MECHANOCHEMICAL GRINDING
Friscic T, Jones W
ANN CHIM-SCI MAT 2009, 34, 415-428. DOI: 10.3166/acsm.34.415-428

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression.
Fernando H, Sewitz S, Darot J, Tavaré S, Huppert JL, Balasubramanian S
Cell Line, Tumor, DNA, G-Quadruplexes, Gene Expression Regulation, Genome, Human, Humans, Promoter Regions, Genetic, Single-Chain Antibodies, Transcription Initiation Site, Transcription, Genetic 2009, 15, 6716-6722. DOI: 10.1093/nar/gkp740

Metal-Hydride Bonding in Higher Alkali Metal Boron Monohydrides
Haywood J, Wheatley AEH
EUR J INORG CHEM 2009, 5010-5016. DOI: 10.1002/ejic.200900756

Synergic Sedation of Sensitive Anions: Alkali-Mediated Zincation of Cyclic Ethers and Ethene
Kennedy AR, Klett J, Mulvey RE, Wright DS
SCIENCE 2009, 326, 706-708. DOI: 10.1126/science.1178165

Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments.
Shim JU, Olguin LF, Whyte G, Scott D, Babtie A, Abell C, Huck WT, Hollfelder F
Alkaline Phosphatase, Escherichia coli, Gene Expression, Kinetics, Luminescent Proteins, Microfluidic Analytical Techniques 2009, 36, 15251-15256. DOI: 10.1021/ja904823z

Deprotection, tethering, and activation of a one-legged metalloporphyrin on a chemically active metal surface: NEXAFS, synchrotron XPS, and STM study of [SAc]P-Mn(III)Cl on Ag(100).
Turner M, Vaughan OP, Kyriakou G, Watson DJ, Scherer LJ, Papageorgiou AC, Sanders JK, Lambert RM
2009, 3, 14913-14919. DOI: 10.1021/ja904664e

Polymer-Mediated Dispersion of Gold Nanoparticles: Using Supramolecular Moieties on the Periphery
Celiz AD, Lee TC, Scherman OA
ADV MATER 2009, 21, 3937-+. DOI: 10.1002/adma.200901291

Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol
Karki S, Friscic T, Fabian L, Laity PR, Day GM, Jones W
ADV MATER 2009, 21, 3905-+. DOI: 10.1002/adma.200900533

Water-gas shift reaction catalyzed by redox enzymes on conducting graphite platelets.
Lazarus O, Woolerton TW, Parkin A, Lukey MJ, Reisner E, Seravalli J, Pierce E, Ragsdale SW, Sargent F, Armstrong FA
J Am Chem Soc 2009, 131, 14154-14155. DOI: 10.1021/ja905797w

Sequence-specific self-sorting of the binding sites of a ditopic guest by cucurbituril homologues and subsequent formation of a hetero[4]pseudorotaxane.
Celtek G, Artar M, Scherman OA, Tuncel D
Binding Sites, Macrocyclic Compounds, Mass Spectrometry, Molecular Structure, Rotaxanes 2009, 15, 10360-10363. DOI: 10.1002/chem.200901504

Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms.
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WT, Gautrot JE
Ethylene Glycol, Polymers, Proteins, Spectrum Analysis, Surface Plasmon Resonance, X-Rays 2009, 23, 2885-2894. DOI: 10.1021/bm900706r

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans.
Lehrbach NJ, Armisen J, Lightfoot HL, Murfitt KJ, Bugaut A, Balasubramanian S, Miska EA
Animals, Animals, Genetically Modified, Base Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Differentiation, Gene Expression Regulation, MicroRNAs, Models, Biological, Molecular Sequence Data, Nucleotidyltransferases, RNA Processing, Post-Transcriptional, Repressor Proteins, Ribonuclease III, Sequence Homology, Nucleic Acid 2009, 59, 1016-1020. DOI: 10.1038/nsmb.1675

Form leading to function
Scherman OA
NAT CHEM 2009, 1, 524-525. DOI: 10.1038/nchem.387

Mastering the chemical language of bacteria.
Galloway WR, Hodgkinson JT, Welch M, Spring DR
4-Butyrolactone, Bacterial Proteins, Crystallography, X-Ray, Protein Binding, Pseudomonas aeruginosa, Quorum Sensing, Small Molecule Libraries, Terphenyl Compounds, Trans-Activators 2009, 4, 913-914. DOI: 10.1016/j.chembiol.2009.09.006

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
Hsu STD, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S
J AM CHEM SOC 2009, 131, 13399-13409. DOI: 10.1021/ja904007p

Synergic anion and cation coordination using the tripodal aluminate anion [MeAl(2-py)(3)](-) (py = 2-pyridyl).
Bullock TH, Chan WT, Wright DS
2009, 0, 6709-6711. DOI: 10.1039/b909933f

G-Quadruplex DNA Bound by a Synthetic Ligand is Highly Dynamic
Jena PV, Shirude PS, Okumus B, Laxmi-Reddy K, Godde F, Huc I, Balasubramanian S, Ha T
J AM CHEM SOC 2009, 131, 12522-+. DOI: 10.1021/ja903408r

A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression
Waller ZAE, Sewitz SA, Hsu STD, Balasubramanian S
J AM CHEM SOC 2009, 131, 12628-12633. DOI: 10.1021/ja901892u

Following the surface response of caffeine cocrystals to controlled humidity storage by atomic force microscopy.
Cassidy AM, Gardner CE, Jones W
Caffeine, Chemistry, Pharmaceutical, Crystallization, Drug Stability, Drug Storage, Excipients, Humidity, Malonates, Microscopy, Atomic Force, Oxalic Acid, X-Ray Diffraction 2009, 4, 59-66. DOI: 10.1016/j.ijpharm.2009.06.009

Recent perspectives on main group-mediated dehydrocoupling of P-P bonds.
Less RJ, Melen RL, Naseri V, Wright DS
2009, 11, 4929-4937. DOI: 10.1039/b907823a

Enantioselective Synthesis of the Lyngbouilloside Macrolactone Core
Webb D, van den Heuvel A, Kogl M, Ley SV
lyngbouilloside, lactone, ring-closing metathesis, dithiane, HARE DOLABELLA-AURICULARIA, DELTA-LACTOL ANIONS, NATURAL-PRODUCTS, MARINE CYANOBACTERIA, ASYMMETRIC-SYNTHESIS, LYNGBYA-BOUILLONII, ORGANIC-SYNTHESIS, MACROLIDE, CONFIGURATION, BRYOSTATINS 2009, 6, 2320-2324. DOI: 10.1055/s-0029-1217707

Pd-EnCat (TM) TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-Substituted Acetylenes via Microwave-Assisted Sonogashira Type Reactions
Sedelmeier J, Ley SV, Lange H, Baxendale IR
Cross-coupling, Heterogeneous catalysis, Reusable catalyst, Palladium, Microwave chemistry, Enynes, COPPER-FREE SONOGASHIRA, CROSS-COUPLING REACTIONS, SUPPORTED PALLADIUM CATALYST, BOND FORMATION, IONIC LIQUIDS, LIGAND-FREE, BROMIDES, WATER, ALKYNYLATION, CHEMISTRY 2009, 16, 4412-4420. DOI: 10.1002/ejoc.200900344

CINF 18-Reliable reactions and stable structures
Goodman JM
ABSTR PAP AM CHEM S 2009, 238, -.

Studies toward a total synthesis of the aplyronines
Lee LYW, Atkinson SJ, Fink SJ, Blakey SB, Paterson I
ABSTR PAP AM CHEM S 2009, 238, -.

Development of inhibitors for Mycobacterium tuberculosis pantothenate synthetase using a fragment-based approach
Hung AW, Silvestre L, Ciulli A, Wen S, Blundell TL, Abell C
ABSTR PAP AM CHEM S 2009, 238, 698-698.

Development of fluorination methods using continuous-flow microreactors
Baumann M, Baxendale IR, Martin LJ, Ley SV
TETRAHEDRON 2009, 65, 6611-6625. DOI: 10.1016/j.tet.2009.05.083

To Switch or Not To Switch: The Effects of Potassium and Sodium Ions on alpha-Poly-L-glutamate Conformations in Aqueous Solutions
Fedorov MV, Goodman JM, Schumm S
J AM CHEM SOC 2009, 131, 10854-+. DOI: 10.1021/ja9030374

Conformational changes of trialanine in sodium halide solutions: An in silico study
Fedorov MV, Goodman JM, Kolombet VV, Schumm S, Socorro IM
JOURNAL OF MOLECULAR LIQUIDS 2009, 147, 117-123. DOI: 10.1016/j.molliq.2008.10.004

Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors.
Myers RM, Shearman JW, Kitching MO, Ramos-Montoya A, Neal DE, Ley SV
Animals, Biological Markers, Disease Progression, Humans, Neoplasms, Protein Binding, Receptors, Neurotensin 2009, 13, 503-525. DOI: 10.1021/cb900038e

The Carbanionic Phosphoylide Dianion [PhP(CH2)(3)](2-), Isoelectronic with Phosphonate Dianions [RP(O)(3)](2-)
Less RJ, Naseri V, Wright DS
ORGANOMETALLICS 2009, 28, 3594-3596. DOI: 10.1021/om9001704

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Palmieri A, Ley SV, Hammond K, Polyzos A, Baxendale IR
TETRAHEDRON LETT 2009, 50, 3287-3289. DOI: 10.1016/j.tetlet.2009.02.059

Synthesis and stereochemical determination of the spirastrellolides.
Paterson I, Dalby SM
Animals, Antimitotic Agents, Macrolides, Marine Biology, Molecular Structure, Porifera, Stereoisomerism 2009, 10, 865-873. DOI: 10.1039/b906991g

Thin catalytic coatings on microreactor walls A way to make industrial processes more efficient
Rebrov EV, Berenguer-Murcia A, Wheatley AEH, Johnson BFG, Schouten JC
CHIM OGGI 2009, 27, 4-7.

Dynamic combinatorial synthesis of a catenane based on donor-acceptor interactions in water
Au-Yeung HY, Pantos GD, Sanders JKM
P NATL ACAD SCI USA 2009, 106, 10466-10470. DOI: 10.1073/pnas.0809934106

White phosphorus is air-stable within a self-assembled tetrahedral capsule.
Mal P, Breiner B, Rissanen K, Nitschke JR
2009, 135, 1697-1699. DOI: 10.1126/science.1175313

Simultaneous measurement of reactions in microdroplets filled by concentration gradients.
Damean N, Olguin LF, Hollfelder F, Abell C, Huck WT
Alkaline Phosphatase, Equipment Design, Escherichia coli, Microfluidic Analytical Techniques, Protein Binding, Protein Denaturation, Time Factors, Titrimetry 2009, 16, 1707-1713. DOI: 10.1039/b821021g

Assigning the stereochemistry of pairs of diastereoisomers using GIAO NMR shift calculation.
Smith SG, Goodman JM
Alcohols, Esters, Lactones, Magnetic Resonance Spectroscopy, Organic Chemicals, Stereoisomerism 2009, 23, 4597-4607. DOI: 10.1021/jo900408d

Interplay of interactions governing the dynamic conversions of acyclic and macrocyclic helicates.
Campbell VE, de Hatten X, Delsuc N, Kauffmann B, Huc I, Nitschke JR
Catalysis, Copper, Crystallography, X-Ray, Hydrocarbons, Acyclic, Macrocyclic Compounds, Magnetic Resonance Spectroscopy, Molecular Structure, Organometallic Compounds, Thermodynamics 2009, 8, 6138-6142. DOI: 10.1002/chem.200900693

Controlled catch and release of small molecules with cucurbit[6]uril via a kinetic trap.
Liu L, Nouvel N, Scherman OA
Bridged Compounds, Crystallography, X-Ray, Diffusion, Ether, Ethyl, Imidazoles, Kinetics, Magnetic Resonance Spectroscopy 2009, 3243-3245. DOI: 10.1039/b903033f

Synthesis of a fullerene-based one-dimensional nanopolymer through topochemical transformation of the parent nanowire
Geng J, Solov'yov IA, Reid DG, Skelton P, Wheatley AEH, Solov'yov AV, Johnson BFG
2009, -.

CHEMICAL SAFETY Mg3N2 EXPLOSION RISK
Ley SV
CHEM ENG NEWS 2009, 87, 4-4.

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes.
Payne RJ, Bulloch EM, Toscano MM, Jones MA, Kerbarh O, Abell C
Anthranilate Synthase, Bacterial Proteins, Carbon-Nitrogen Ligases, Chorismic Acid, Enzyme Inhibitors, Escherichia coli, Intramolecular Transferases, Lyases, Serratia marcescens, Transaminases 2009, 5, 2421-2429. DOI: 10.1039/b901694e

An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets.
Hufnagel H, Huebner A, Gülch C, Güse K, Abell C, Hollfelder F
Animals, CHO Cells, Cell Culture Techniques, Cell Proliferation, Cell Survival, Cells, Immobilized, Cricetinae, Cricetulus, Equipment Design, Genes, Reporter, Green Fluorescent Proteins, Microfluidic Analytical Techniques, Microtechnology, Transfection 2009, 21, 1576-1582. DOI: 10.1039/b821695a

G-quadruplex nucleic acids as therapeutic targets
Balasubramanian S, Neidle S
CURR OPIN CHEM BIOL 2009, 13, 345-353. DOI: 10.1016/j.cbpa.2009.04.637

Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success?
Page SM, Boss SR, Barker PD
FUTURE MED CHEM 2009, 1, 541-559. DOI: 10.4155/FMC.09.25

Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches.
Agyei-Owusu K, Leeper FJ
Binding Sites, Catalysis, Humans, Kinetics, Molecular Structure, Pyruvate Decarboxylase, RNA, Messenger, Regulatory Sequences, Ribonucleic Acid, Substrate Specificity, Thiamine Pyrophosphate 2009, 8, 2905-2916. DOI: 10.1111/j.1742-4658.2009.07018.x

The discovery of antibacterial agents using diversity-oriented synthesis.
Galloway WR, Bender A, Welch M, Spring DR
Anti-Bacterial Agents, Combinatorial Chemistry Techniques, Drug Discovery, Drug Evaluation, Preclinical, Genetics, Small Molecule Libraries 2009, 27, 2446-2462. DOI: 10.1039/b816852k

A Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles
Baxendale IR, Buckle CD, Ley SV, Tamborini L
SYNTHESIS-STUTTGART 2009, 1485-1493. DOI: 10.1055/s-0028-1087991

Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?
Galloway WRJD, Spring DR
diversity, diversity-oriented synthesis, drug discovery, library synthesis, ORIENTED SYNTHESIS, NATURAL-PRODUCTS, MOLECULAR DIVERSITY, DRUG DISCOVERY, CHEMICAL SPACE, CHEMISTRY, STRATEGY, INHIBITOR, SCAFFOLDS, BIOLOGY 2009, 11, 467-472. DOI: 10.1517/17460440902916606

Merging microdroplets with laminar flow microfluidics
Abell C, Huck W, Bratton D, Whyte G, Fidalgo L
2009, -.

Fragment-based drug discovery in academia: Experiences from a tuberculosis programme
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield KM, Scott DE, Howard NI, Wen S, Wei AH, Osborne DM, Abell C, Blundell TL
2009, 21-36.

Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays.
Courtois F, Olguin LF, Whyte G, Theberge AB, Huck WT, Hollfelder F, Abell C
Animals, Cattle, Emulsions, Escherichia coli, Fluorescein, Microfluidic Analytical Techniques, Microscopy, Fluorescence, Microspheres, Mineral Oil, Water 2009, 31, 3008-3016. DOI: 10.1021/ac802658n

Formation of an Organometallic Phosphanediide via Main-Group Dehydrocoupling
Less RJ, Naseri V, Wright DS
ORGANOMETALLICS 2009, 28, 1995-1997. DOI: 10.1021/om9000296

Total synthesis of (-)-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium cellulosum.
Paterson I, Findlay AD, Noti C
Acetals, Antimitotic Agents, Fatty Acids, Unsaturated, Myxococcales, Stereoisomerism 2009, 14, 594-611. DOI: 10.1002/asia.200800445

Variant c-type cytochromes as probes of the substrate specificity of the E. coli cytochrome c maturation (Ccm) apparatus
Allen JWA, Sawyer EB, Ginger ML, Barker PD, Ferguson SJ
BIOCHEM J 2009, 419, 177-184. DOI: 10.1042/BJ20081999

AuCl3-Catalyzed Hydroalkoxylation of Conjugated Alkynoates: Synthesis of Five- and Six-Membered Cyclic Acetals
Dieguez-Vazquez A, Tzschucke CC, Crecente-Campo J, McGrath S, Ley SV
EUR J ORG CHEM 2009, 1698-1706. DOI: 10.1002/ejoc.200801221

Hydrogen bonding and pi-stacking: how reliable are force fields? A critical evaluation of force field descriptions of nonbonded interactions.
Paton RS, Goodman JM
Computer Simulation, Databases, Factual, Dimerization, Energy Transfer, Hydrogen Bonding 2009, 33, 944-955. DOI: 10.1021/ci900009f

Mechanism of BINOL--phosphoric acid-catalyzed strecker reaction of benzyl imines.
Simón L, Goodman JM
2009, 34, 4070-4077. DOI: 10.1021/ja808715j

Cucurbiturils in aqueous supramolecular polymers
Scherman OA
ABSTR PAP AM CHEM S 2009, 237, -.

Fluoride-free cross coupling using vinyldisiloxanes.
Sore HF, Boehner CM, MacDonald SJ, Norton D, Fox DJ, Spring DR
Catalysis, Hydrocarbons, Brominated, Hydrocarbons, Iodinated, Molecular Structure, Palladium, Siloxanes, Stereoisomerism, Stilbenes 2009, 10, 1068-1072. DOI: 10.1039/b900852g

A meta-selective copper-catalyzed C-H bond arylation.
Phipps RJ, Gaunt MJ
Acetanilides, Anilides, Benzene, Carbon, Catalysis, Chemical Phenomena, Copper, Hydrogen, Isomerism, Molecular Structure, Oxidation-Reduction 2009, 151, 1593-1597. DOI: 10.1126/science.1169975

Synthetic Studies on Siphonariid Polypropionates: Synthesis and Isomerization of the Caloundrin B Trioxaadamantane Ring System
Beye GE, Goodman JM, Ward DE
ORG LETT 2009, 11, 1373-1376. DOI: 10.1021/ol900192q

Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
Paterson I, Gardner NM, Guzmán E, Wright AE
Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Macrolides, Models, Molecular, Spectrum Analysis 2009, 12, 2282-2289. DOI: 10.1016/j.bmc.2008.10.084

A route to enantiomerically pure 5-(2 '-hydroxyethyl)cyclopent-2-en-1-ol and its absolute configuration by Mosher esters
Chen H, Nagabandi S, Smith S, Goodman JM, Plettner E
TETRAHEDRON-ASYMMETR 2009, 20, 449-456. DOI: 10.1016/j.tetasy.2009.02.007

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays.
Huebner A, Bratton D, Whyte G, Yang M, Demello AJ, Abell C, Hollfelder F
Algorithms, Biological Assay, Dimethylpolysiloxanes, Enzymes, Equipment Design, Escherichia coli, Fluorescence, Galactosidases, Lasers, Luminescent Proteins, Microfluidics, Nanotechnology, Sulfolobus 2009, 58, 692-698. DOI: 10.1039/b813709a

Recent Advances in Understanding the Mechanism of Cocrystal Formation via Grinding
Friscic T, Jones W
CRYST GROWTH DES 2009, 9, 1621-1637. DOI: 10.1021/cg800764n

Testing the Sensitivity of Terahertz Spectroscopy to Changes in Molecular and Supramolecular Structure: A Study of Structurally Similar Cocrystals
Parrott EPJ, Zeitler JA, Friscic T, Pepper M, Jones W, Day GM, Gladden LF
CRYST GROWTH DES 2009, 9, 1452-1460. DOI: 10.1021/cg8008893

The effect of sodium chloride on poly-l-glutamate conformation.
Fedorov MV, Goodman JM, Schumm S
Computer Simulation, Molecular Conformation, Polyglutamic Acid, Sodium Chloride 2009, 16, 896-898. DOI: 10.1039/b816055d

Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis.
Evans AC, Longbottom DA, Matsuoka M, Davies JE, Turner R, Franckevicius V, Ley SV
Anhydrides, Biological Agents, Immunosuppressive Agents, Methods, Sirolimus, Stereoisomerism 2009, 4, 747-760. DOI: 10.1039/b813494d

Discrete, multi-component complexes with cucurbit[8]uril in the gas-phase.
Deroo S, Rauwald U, Robinson CV, Scherman OA
2009, 644-646. DOI: 10.1039/b818369d

Metal and ligand substitution of the aluminium tris-pyridyl ligands [RAl(2-py')(3)](-) (R = Et, (n)Bu, (s)Bu, (t)Bu; 2-py' = 2-pyridyl, 3-methyl-2-pyridyl, 5-methyl-2-pyridyl, 6-methyl-2-pyridyl).
Bullock TH, Chan WT, Eisler DJ, Streib M, Wright DS
2009, 2, 1046-1054. DOI: 10.1039/b815057e

Deprotection, Tethering, and Activation of a Catalytically Active Metalloporphyrin to a Chemically Active Metal Surface: [SAc](4)P-Mn(III)Cl on Ag(100)
Turner M, Vaughan OPH, Kyriakou G, Watson DJ, Scherer LJ, Davidson GJE, Sanders JKM, Lambert RM
SELF-ASSEMBLED MONOLAYERS, OXIDATION, GOLD, PORPHYRINS, CATALYST, THIOLS 2009, 5, 1910-1914. DOI: 10.1021/ja8076389

Towards quorum-quenching catalytic antibodies.
Kapadnis PB, Hall E, Ramstedt M, Galloway WR, Welch M, Spring DR
Acyl-Butyrolactones, Anti-Bacterial Agents, Antibodies, Catalytic, Bacterial Proteins, Hydrolysis, Quorum Sensing, Sulfones 2009, 11, 538-540. DOI: 10.1039/b819819e

What is the mechanism of amine conjugate additions to pyrazole crotonate catalyzed by thiourea catalysts?
Simón L, Goodman JM
2009, 5, 483-487. DOI: 10.1039/b817283h

Catalytic electrochemistry of a [NiFeSe]-hydrogenase on TiO2 and demonstration of its suitability for visible-light driven H2 production.
Reisner E, Fontecilla-Camps JC, Armstrong FA
Chem Commun (Camb) 2009, 550-552. DOI: 10.1039/b817371k

Toward the total synthesis of the brasilinolides: construction of a differentially protected C20-C38 segment.
Paterson I, Burton PM, Cordier CJ, Housden MP, Mühlthau FA, Loiseleur O
Catalysis, Ketones, Macrolides, Molecular Structure, Pyrans, Stereoisomerism 2009, 4, 693-696. DOI: 10.1021/ol802769e

Evidence for the formation of anhydrous zinc acetate and acetic anhydride during the thermal degradation of zinc hydroxy acetate, Zn-5(OH)(8)(CH3CO2)(2)center dot 4H(2)O to ZnO
Biswick T, Jones W, Pacula A, Serwicka E, Podobinski J
SOLID STATE SCI 2009, 11, 330-335. DOI: 10.1016/j.solidstatesciences.2008.06.018

Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents
Paterson I, Gardner NM, Naylor GJ
PURE AND APPLIED CHEMISTRY 2009, 81, 169-180. DOI: 10.1351/PAC-CON-08-09-17

Toward the total synthesis of the brasilinolides: stereocontrolled assembly of a C1-C19 polyol segment.
Paterson I, Mühlthau FA, Cordier CJ, Housden MP, Burton PM, Loiseleur O
Aldehydes, Carbon, Macrolides, Polymers, Stereoisomerism 2009, 7, 353-356. DOI: 10.1021/ol802562b

Gilman-Type versus Lipshutz-Type Reagents: Competition in Lithiocuprate Chemistry
Haywood J, Morey JV, Wheatley AEH, Liu CY, Yasuike S, Kurita J, Uchiyama M, Raithby PR
ORGANOMETALLICS 2009, 28, 38-41. DOI: 10.1021/om801101u

Mechanistic insights into the catalytic asymmetric allylboration of ketones: Brønsted or Lewis acid activation?
Paton RS, Goodman JM, Pellegrinet SC
Allyl Compounds, Boranes, Boronic Acids, Catalysis, Ketones, Ligands, Models, Chemical, Molecular Structure, Naphthols, Stereoisomerism 2009, 8, 37-40. DOI: 10.1021/ol802270u

Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets.
Schaerli Y, Wootton RC, Robinson T, Stein V, Dunsby C, Neil MA, French PM, Demello AJ, Abell C, Hollfelder F
DNA, Electrophoresis, Fluorescent Dyes, Microfluidic Analytical Techniques, Oils, Polymerase Chain Reaction, Polymethyl Methacrylate, Rhodamines, Temperature, Water 2009, 60, 302-306. DOI: 10.1021/ac802038c

Findings of the Challenge To Predict Aqueous Solubility
Hopfinger AJ, Esposito EX, Llinas A, Glen RC, Goodman JM
J CHEM INF MODEL 2009, 49, 1-5. DOI: 10.1021/ci800436c

Dynamic electrochemical investigations of hydrogen oxidation and production by enzymes and implications for future technology.
Armstrong FA, Belsey NA, Cracknell JA, Goldet G, Parkin A, Reisner E, Vincent KA, Wait AF
Anaerobiosis, Bacteria, Bacterial Proteins, Carbon Dioxide, Catalytic Domain, Electrochemical Techniques, Electrodes, Energy-Generating Resources, Enzymes, Immobilized, Hydrogen, Hydrogen Sulfide, Hydrogenase, Oxidation-Reduction, Oxygen, Photochemical Processes, Platinum 2009, 56, 36-51. DOI: 10.1039/b801144n

Synergic Sedation of Sensitive Anions: Alkali-Mediated Zincation of Cyclic Ethers and Ethene
Alan R Kennedy, Jan Klett, Robert E Mulvey, Dominic S Wright
Science DOI: 10.1126/science.1181863

Synthesis of unprecedented scaffold diversity.
Galloway WR, Diáz-Gavilán M, Isidro-Llobet A, Spring DR
Biological Factors, Combinatorial Chemistry Techniques, Small Molecule Libraries 2009, 16, 1194-1196. DOI: 10.1002/anie.200805452

The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome
Friscic T, Childs SL, Rizvi SAA, Jones W
CRYSTENGCOMM 2009, 11, 418-426. DOI: 10.1039/b815174a

The crystal structures of three novel lutidinium pamoate salts
Haynes DA, Weng ZF, Jones W, Motherwell WDS
CRYSTENGCOMM 2009, 11, 254-260. DOI: 10.1039/b814214a

Control and interconversion of cocrystal stoichiometry in grinding: stepwise mechanism for the formation of a hydrogen-bonded cocrystal
Karki S, Friscic T, Jones W
CRYSTENGCOMM 2009, 11, 470-481. DOI: 10.1039/b812531g

Total synthesis of rapamycin.
Ley SV, Tackett MN, Maddess ML, Anderson JC, Brennan PE, Cappi MW, Heer JP, Helgen C, Kori M, Kouklovsky C, Marsden SP, Norman J, Osborn DP, Palomero MA, Pavey JB, Pinel C, Robinson LA, Schnaubelt J, Scott JS, Spilling CD, Watanabe H, Wesson KE, Willis MC
Antineoplastic Agents, Biological Agents, Cyclization, Humans, Immunosuppressive Agents, Molecular Structure, Sirolimus 2009, 14, 2874-2914. DOI: 10.1002/chem.200801656

Total synthesis of (-)-spirangien a and the corresponding methyl ester
Cranwell PB, Ley SV
Chemtracts 2009, 22, 173-181.

TOTAL SYNTHESIS OF THE POTENT ANTIFUNGAL AGENTS BENGAZOLE C AND E
Enriquez-Garcia A, Ley SV
COLLECT CZECH CHEM C 2009, 74, 887-900. DOI: 10.1135/cccc2009016

Synthesis of Azadirachtin: A long but successful journey
Veitch GE, Beckmann E, Burke BJ, Boyer A, Maslen SL, Ley SV
Chemtracts 2009, 22, 214-217.

Second-generation synthesis of azadirachtin: a concise preparation of the propargylic mesylate fragment.
Boyer A, Veitch GE, Beckmann E, Ley SV
Catalysis, Lactones, Limonins, Mesylates, Stereoisomerism 2009, 5, 1317-1320. DOI: 10.1002/anie.200805395

The discovery and development of the green fluorescent protein, GFP
Sanders JKM, Jackson SE
Chemical Society Reviews 2009, 38, 2821-2822.

The discovery and development of the green fluorescent protein, GFP
Sanders JKM, Jackson SE
CHEM SOC REV 2009, 38, 2821-2822. DOI: 10.1039/b917331p

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
Redman JE, Granadino-Roldan JM, Schouten JA, Ladame S, Reszka AP, Neidle S, Balasubramanian S
ORG BIOMOL CHEM 2009, 7, 76-84. DOI: 10.1039/b814682a

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
Muller S, Pantos GD, Rodriguez R, Balasubramanian S
CHEM COMMUN 2009, 80-82. DOI: 10.1039/b816861j

Formation of a new class of 7 pi radicals via sterically induced P-P bond cleavage of the dimers [(CH)(2)(NR)(2)P](2)
Edge R, Less RJ, McInnes EJL, Muther K, Naseri V, Rawson JM, Wright DS
CHEM COMMUN 2009, 1691-1693. DOI: 10.1039/b821241d

Interfacial redox processes of cytochrome b(562)
Zuo P, Albrecht T, Barker PD, Murgida DH, Hildebrandt P
PHYS CHEM CHEM PHYS 2009, 11, 7430-7436. DOI: 10.1039/b904926f

Supramolecular chemistry: Form leading to function
Scherman OA
Nature Chemistry 2009, 1, 524-525.

Crown-ether- and porphyrin-attached gel-phase resins in thermodynamically controlled rotaxane assembly
Mullen KM, Johnstone KD, Nath D, Bampos N, Sanders JKM, Gunter MJ
ORG BIOMOL CHEM 2009, 7, 293-303. DOI: 10.1039/b816115a

Alumni Profiles
Nitschke JR, Quattropani A, Corminboeuf C, Velonia K, Wilkinson KJ, Kubel F
CHIMIA 2009, 63, 874-+. DOI: 10.2533/chimia.2009.874

Reaxys
Goodman J
JOURNAL OF CHEMICAL INFORMATION AND MODELING 2009, 49, {2897-2898}-{2897-2898}. DOI: 10.1021/ci900437n

Joining the crown family; the tetrameric, O-bridged macrocycle [{P(mu-(NBu)-Bu-t)}(2)(mu-O)](4)
Calera SG, Eisler DJ, Goodman JM, McPartlin M, Singh S, Wright DS
DALTON T 2009, 1293-1296. DOI: 10.1039/b900268p

Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water
Au-Yeung HY, Pengo P, Pantos GD, Otto S, Sanders JKM
CHEM COMMUN 2009, 419-421. DOI: 10.1039/b816979a

Electronic structure and circular dichroism spectroscopy of naphthalenediimide nanotubes
Bulheller BM, Pantoş GD, Sanders JKM, Hirst JD
Physical Chemistry Chemical Physics 2009, 11, 6060-6065.

Electronic structure and circular dichroism spectroscopy of naphthalenediimide nanotubes
Bulheller BM, Pantos GD, Sanders JKM, Hirst JD
PHYS CHEM CHEM PHYS 2009, 11, 6060-6065. DOI: 10.1039/b905187b

Multistep synthesis using modular flow reactors: Bestmann-ohira reagent for the formation of alkynes and triazoles
Baxendale IR, Ley SV, Mansfield AC, Smith CD
Angewandte Chemie - International Edition 2009, 48, 4017-4021.

Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles.
Baxendale IR, Ley SV, Mansfield AC, Smith CD
Angew Chem Int Ed Engl 2009, 48, 4017-4021. DOI: 10.1002/anie.200900970

Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.
Palmieri A, Ley SV, Polyzos A, Ladlow M, Baxendale IR
2009, 5, 23 -. DOI: 10.3762/bjoc.5.23

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process
Sedelmeier J, Ley SV, Baxendale IR
GREEN CHEM 2009, 11, 683-685. DOI: 10.1039/b821752a

The Chemical Synthesis of Discodermolide
Paterson I, Florence GJ
TOP CURR CHEM 2009, 286, 73-119. DOI: 10.1007/128_2008_7

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents
Paterson I, Findlay AD
AUSTRALIAN JOURNAL OF CHEMISTRY 2009, 62, 624-638. DOI: 10.1071/CH09104

Structurally Defined Potassium-Mediated Zincation of Pyridine and 4-R-Substituted Pyridines (R = Et, iPr, tBu, Ph, and Me2N) by Using Dialkyl-TMP-Zincate Bases
Clegg W, Conway B, Graham DV, Hevia E, Kennedy AR, Mulvey RE, Russo L, Wright DS
CHEM-EUR J 2009, 15, 7074-7082. DOI: 10.1002/chem.200900549

Group 2 (Be-Ba) and group 12 (Zn-Hg)
García F, Wright DS
Organometallic Chemistry 2009, 35, 162-182.

Bimetallic PdZn Nanoparticles for the Partial Hydrogenation of Phenylacetylene
Engels V, Wheatley AEH, Berenguer-Murcia A, Jefferson DA, Johnson BFG
RECENT DEVELOPMENTS IN THE PROCESSING AND APPLICATIONS OF STRUCTURAL METALS AND ALLOYS 2009, 604-605, 13-17.

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.
Fidalgo LM, Whyte G, Ruotolo BT, Benesch JL, Stengel F, Abell C, Robinson CV, Huck WT
2009, 36, 3665-3668. DOI: 10.1002/anie.200806103

FRAGMENT-BASED DRUG DISCOVERY IN ACADEMIA: EXPERIENCES FROM A TUBERCULOSIS PROGRAMME
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen SJ, Wei AH, Osborne D, Abell C, Blundell TL
FROM MOLECULES TO MEDICINES 2009, 21-36.

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C
Enzyme Inhibitors, Humans, Models, Molecular, Mycobacterium tuberculosis, Peptide Synthases, Protein Conformation, Stereoisomerism 2009, 19, 8452-8456. DOI: 10.1002/anie.200903821

Two-phase dynamic combinatorial discovery of a spermine transporter
Perez-Fernandez R, Pittelkow M, Belenguer AM, Lane LA, Robinson CV, Sanders JKM
CHEM COMMUN 2009, 3708-3710. DOI: 10.1039/b902842k

Capillary microreactors wall-coated with mesoporous titania thin film catalyst supports
Rebrov EV, Berenguer-Murcia A, Skelton HE, Johnson BFG, Wheatley AEH, Schouten JC
LAB CHIP 2009, 9, 503-506. DOI: 10.1039/b815716b

Alkali/coinage metals-organolithium, organocuprate chemistry
Haywood J, Wheatley AEH
Organometallic Chemistry 2009, 35, 130-161.

Fragment-based drug discovery in academia: Experiences from a tuberculosis programme
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL
NATO Security through Science Series C: Environmental Security 2009, 21-36.