Department of Chemistry

Synthesis Publications (2009)

Visible light-driven H(2) production by hydrogenases attached to dye-sensitized TiO(2) nanoparticles.
Reisner E, Powell DJ, Cavazza C, Fontecilla-Camps JC, Armstrong FA
J Am Chem Soc, 2009, 51, 18457-18466. DOI: 10.1021/ja907923r

Functional and Tuneable Amino Acid Polymers Prepared by RAFT Polymerization
Evans AC, Skey J, Wright M, Qu WJ, Ondeck C, Longbottom DA, O'Reilly RK
J POLYM SCI POL CHEM, 2009, 24, 6814-6826. DOI: 10.1002/pola.23721

3D small-molecule microarrays.
Marsden DM, Nicholson RL, Ladlow M, Spring DR
Chem Commun (Camb), 2009, 46, 7107-7109. DOI: 10.1039/b913665g

Systems chemistry: Molecular networks come of age.
Nitschke JR
Nature, 2009, 7274, 736-738. DOI: 10.1038/462736a

Predicting inclusion behaviour and framework structures in organic crystals.
Cruz-Cabeza AJ, Day GM, Jones W
Chemistry, 2009, 47, 13033-13040. DOI: 10.1002/chem.200901703

Confined palladium colloids in mesoporous frameworks for carbon nanotube growth
Berenguer-Murcia A, Rebrov EV, Cabaj M, Wheatley AEH, Johnson BFG, Robertson J, Schouten JC
JOURNAL OF MATERIALS SCIENCE, 2009-12, 24, 6563-6570. DOI: 10.1007/s10853-009-3629-y

Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.
Ashbridge B, Orte A, Yeoman JA, Kirwan M, Vulliamy T, Dokal I, Klenerman D, Balasubramanian S
Biochemistry, 2009, 46, 10858-10865. DOI: 10.1021/bi901373e

Single-Molecule Analysis of the Human Telomerase RNA center dot Dyskerin Interaction and the Effect of Dyskeratosis Congenita Mutations
Ashbridge B, Orte A, Yeoman JA, Kirwan M, Vulliamy T, Dokal I, Klenerman D, Balasubramanian S
BIOCHEMISTRY-US, 2009, 46, 10858-10865. DOI: 10.1021/bi901373e

A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.
Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A
Chembiochem, 2009, 17, 2772-2779. DOI: 10.1002/cbic.200900537

Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.
Carter CF, Baxendale IR, O'Brien M, Pavey JB, Ley SV
Org Biomol Chem, 2009, 22, 4594-4597. DOI: 10.1039/b917289k

The regioselective photochemical rearrangement of alpha-[PN(t)Bu](4).
Bladt H, Gonzalez Calera S, Goodman JM, Less RJ, Naseri V, Steiner A, Wright DS
Chem Commun (Camb), 2009, 43, 6637-6639. DOI: 10.1039/b914370j

Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxidation: Applications in the Total Synthesis of Ellagitannin Natural Products
Su XB, Thomas GL, Galloway WRJD, Surry DS, Spandl RJ, Spring DR
SYNTHESIS-STUTTGART, 2009, 22, 3880-3896. DOI: 10.1055/s-0029-1218154

Amplifying Different [2]Catenanes in an Aqueous Donor-Acceptor Dynamic Combinatorial Library
Au-Yeung HY, Pantos GD, Sanders JKM
J AM CHEM SOC, 2009, 44, 16030-+. DOI: 10.1021/ja906634h

Friscic T, Jones W
ANN CHIM-SCI MAT, 2009-11, 6, 415-428. DOI: 10.3166/acsm.34.415-428

Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression.
Fernando H, Sewitz S, Darot J, Tavaré S, Huppert JL, Balasubramanian S
Nucleic Acids Res, 2009-11, 20, 6716-6722. DOI: 10.1093/nar/gkp740

Metal-Hydride Bonding in Higher Alkali Metal Boron Monohydrides
Haywood J, Wheatley AEH
EUR J INORG CHEM, 2009-11, 33, 5010-5016. DOI: 10.1002/ejic.200900756

Synergic Sedation of Sensitive Anions: Alkali-Mediated Zincation of Cyclic Ethers and Ethene
Kennedy AR, Klett J, Mulvey RE, Wright DS
SCIENCE, 2009, 5953, 706-708. DOI: 10.1126/science.1178165

Synergic Sedation of Sensitive Anions: Alkali-Mediated Zincation of Cyclic Ethers and Ethene
Alan R Kennedy, Jan Klett, Robert E Mulvey, Dominic S Wright
Science DOI: 10.1126/science.1181863

Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments.
Shim JU, Olguin LF, Whyte G, Scott D, Babtie A, Abell C, Huck WT, Hollfelder F
J Am Chem Soc, 2009, 42, 15251-15256. DOI: 10.1021/ja904823z

Deprotection, tethering, and activation of a one-legged metalloporphyrin on a chemically active metal surface: NEXAFS, synchrotron XPS, and STM study of [SAc]P-Mn(III)Cl on Ag(100).
Turner M, Vaughan OP, Kyriakou G, Watson DJ, Scherer LJ, Papageorgiou AC, Sanders JK, Lambert RM
J Am Chem Soc, 2009, 41, 14913-14919. DOI: 10.1021/ja904664e

Deprotection, Tethering, and Activation of a One-Legged Metalloporphyrin on a Chemically Active Metal Surface: NEXAFS, Synchrotron XPS, and STM Study of [SAc]P-Mn(III)Cl on Ag(100)
Turner M, Vaughan OPH, Kynakou G, Watson DJ, Scherer LJ, Papageorgiou AC, Sanders JKM, Lambert RM
J AM CHEM SOC, 2009, 41, 14913-14919. DOI: 10.1021/ja904664e

Polymer-Mediated Dispersion of Gold Nanoparticles: Using Supramolecular Moieties on the Periphery
Celiz AD, Lee TC, Scherman OA
ADV MATER, 2009, 38-39, 3937-+. DOI: 10.1002/adma.200901291

Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol
Karki S, Friscic T, Fabian L, Laity PR, Day GM, Jones W
ADV MATER, 2009, 38-39, 3905-+. DOI: 10.1002/adma.200900533

Water-gas shift reaction catalyzed by redox enzymes on conducting graphite platelets.
Lazarus O, Woolerton TW, Parkin A, Lukey MJ, Reisner E, Seravalli J, Pierce E, Ragsdale SW, Sargent F, Armstrong FA
J Am Chem Soc, 2009, 40, 14154-14155. DOI: 10.1021/ja905797w

Sequence-specific self-sorting of the binding sites of a ditopic guest by cucurbituril homologues and subsequent formation of a hetero[4]pseudorotaxane.
Celtek G, Artar M, Scherman OA, Tuncel D
Chemistry, 2009, 40, 10360-10363. DOI: 10.1002/chem.200901504

Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms.
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WT, Gautrot JE
Biomacromolecules, 2009, 10, 2885-2894. DOI: 10.1021/bm900706r

Form leading to function
Scherman OA
NAT CHEM, 2009-10, 7, 524-525. DOI: 10.1038/nchem.387

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans.
Lehrbach NJ, Armisen J, Lightfoot HL, Murfitt KJ, Bugaut A, Balasubramanian S, Miska EA
Nat Struct Mol Biol, 2009-10, 10, 1016-1020. DOI: 10.1038/nsmb.1675

Mastering the chemical language of bacteria.
Galloway WR, Hodgkinson JT, Welch M, Spring DR
Chem Biol, 2009, 9, 913-914. DOI: 10.1016/j.chembiol.2009.09.006

A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics
Hsu STD, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S
J AM CHEM SOC, 2009, 37, 13399-13409. DOI: 10.1021/ja904007p

Synergic anion and cation coordination using the tripodal aluminate anion [MeAl(2-py)(3)](-) (py = 2-pyridyl).
Bullock TH, Chan WT, Wright DS
Dalton Trans, 2009, 34, 6709-6711. DOI: 10.1039/b909933f

G-Quadruplex DNA Bound by a Synthetic Ligand is Highly Dynamic
Jena PV, Shirude PS, Okumus B, Laxmi-Reddy K, Godde F, Huc I, Balasubramanian S, Ha T
J AM CHEM SOC, 2009, 35, 12522-+. DOI: 10.1021/ja903408r

A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression
Waller ZAE, Sewitz SA, Hsu STD, Balasubramanian S
J AM CHEM SOC, 2009, 35, 12628-12633. DOI: 10.1021/ja901892u

Following the surface response of caffeine cocrystals to controlled humidity storage by atomic force microscopy.
Cassidy AM, Gardner CE, Jones W
Int J Pharm, 2009, 1, 59-66. DOI: 10.1016/j.ijpharm.2009.06.009

Recent perspectives on main group-mediated dehydrocoupling of P-P bonds.
Less RJ, Melen RL, Naseri V, Wright DS
Chem Commun (Camb), 2009, 33, 4929-4937. DOI: 10.1039/b907823a

Enantioselective Synthesis of the Lyngbouilloside Macrolactone Core
Webb D, van den Heuvel A, Kogl M, Ley SV
SYNLETT, 2009, 14, 2320-2324. DOI: 10.1055/s-0029-1217707

Pd-EnCat (TM) TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl-Substituted Acetylenes via Microwave-Assisted Sonogashira Type Reactions
Sedelmeier J, Ley SV, Lange H, Baxendale IR
EUR J ORG CHEM, 2009-09, 26, 4412-4420. DOI: 10.1002/ejoc.200900344

CINF 18-Reliable reactions and stable structures
Goodman JM

Studies toward a total synthesis of the aplyronines
Lee LYW, Atkinson SJ, Fink SJ, Blakey SB, Paterson I

Development of fluorination methods using continuous-flow microreactors
Baumann M, Baxendale IR, Martin LJ, Ley SV
TETRAHEDRON, 2009, 33, 6611-6625. DOI: 10.1016/j.tet.2009.05.083

To Switch or Not To Switch: The Effects of Potassium and Sodium Ions on alpha-Poly-L-glutamate Conformations in Aqueous Solutions
Fedorov MV, Goodman JM, Schumm S
J AM CHEM SOC, 2009, 31, 10854-+. DOI: 10.1021/ja9030374

Conformational changes of trialanine in sodium halide solutions: An in silico study
Fedorov MV, Goodman JM, Kolombet VV, Schumm S, Socorro IM
JOURNAL OF MOLECULAR LIQUIDS, 2009, 01-Feb, 117-123. DOI: 10.1016/j.molliq.2008.10.004

Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors.
Myers RM, Shearman JW, Kitching MO, Ramos-Montoya A, Neal DE, Ley SV
ACS Chem Biol, 2009, 7, 503-525. DOI: 10.1021/cb900038e

The Carbanionic Phosphoylide Dianion [PhP(CH2)(3)](2-), Isoelectronic with Phosphonate Dianions [RP(O)(3)](2-)
Less RJ, Naseri V, Wright DS
ORGANOMETALLICS, 2009, 13, 3594-3596. DOI: 10.1021/om9001704

A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
Palmieri A, Ley SV, Hammond K, Polyzos A, Baxendale IR
TETRAHEDRON LETT, 2009, 26, 3287-3289. DOI: 10.1016/j.tetlet.2009.02.059

Synthesis and stereochemical determination of the spirastrellolides.
Paterson I, Dalby SM
Nat Prod Rep, 2009-07, 7, 865-873. DOI: 10.1039/b906991g

Thin catalytic coatings on microreactor walls A way to make industrial processes more efficient
Rebrov EV, Berenguer-Murcia A, Wheatley AEH, Johnson BFG, Schouten JC
CHIM OGGI, 2009-07, 4, 4-7.

Dynamic combinatorial synthesis of a catenane based on donor-acceptor interactions in water
Ho YA-Y, Pantoş GD, Sanders JKM
Proceedings of the National Academy of Sciences of the United States of America, 2009, 26, 10466-10470.

White phosphorus is air-stable within a self-assembled tetrahedral capsule.
Mal P, Breiner B, Rissanen K, Nitschke JR
Science, 2009, 5935, 1697-1699. DOI: 10.1126/science.1175313

Simultaneous measurement of reactions in microdroplets filled by concentration gradients.
Damean N, Olguin LF, Hollfelder F, Abell C, Huck WT
Lab Chip, 2009, 12, 1707-1713. DOI: 10.1039/b821021g

Assigning the stereochemistry of pairs of diastereoisomers using GIAO NMR shift calculation.
Smith SG, Goodman JM
J Org Chem, 2009, 12, 4597-4607. DOI: 10.1021/jo900408d

Interplay of interactions governing the dynamic conversions of acyclic and macrocyclic helicates.
Campbell VE, de Hatten X, Delsuc N, Kauffmann B, Huc I, Nitschke JR
Chemistry, 2009, 25, 6138-6142. DOI: 10.1002/chem.200900693

Controlled catch and release of small molecules with cucurbit[6]uril via a kinetic trap.
Liu L, Nouvel N, Scherman OA
Chem Commun (Camb), 2009, 22, 3243-3245. DOI: 10.1039/b903033f

"Synthesis of a fullerene-based one-dimensional nanopolymer through topochemical transformation of the parent nanowire"
Geng J, Solov'yov IA, Reid DG, Skelton P, Wheatley AEH, Solov'yov AV, Johnson BFG
, 2009, -.

Ley SV
CHEM ENG NEWS, 2009, 23, 4-4.

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes.
Payne RJ, Bulloch EM, Toscano MM, Jones MA, Kerbarh O, Abell C
Org Biomol Chem, 2009, 11, 2421-2429. DOI: 10.1039/b901694e

An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets.
Hufnagel H, Huebner A, Gülch C, Güse K, Abell C, Hollfelder F
Lab Chip, 2009, 11, 1576-1582. DOI: 10.1039/b821695a

G-quadruplex nucleic acids as therapeutic targets
Balasubramanian S, Neidle S
CURR OPIN CHEM BIOL, 2009-06, 3, 345-353. DOI: 10.1016/j.cbpa.2009.04.637

Tuning heavy metal compounds for anti-tumor activity: is diversity the key to ruthenium's success?
Page SM, Boss SR, Barker PD
FUTURE MED CHEM, 2009-06, 3, 541-559. DOI: 10.4155/FMC.09.25

Thiamin diphosphate in biological chemistry: analogues of thiamin diphosphate in studies of enzymes and riboswitches.
Agyei-Owusu K, Leeper FJ
FEBS J, 2009-06, 11, 2905-2916. DOI: 10.1111/j.1742-4658.2009.07018.x

The discovery of antibacterial agents using diversity-oriented synthesis.
Galloway WR, Bender A, Welch M, Spring DR
Chem Commun (Camb), 2009, 18, 2446-2462. DOI: 10.1039/b816852k

A Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles
Baxendale IR, Buckle CD, Ley SV, Tamborini L
SYNTHESIS-STUTTGART, 2009, 9, 1485-1493. DOI: 10.1055/s-0028-1087991

Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?
Galloway WRJD, Spring DR
EXPERT OPIN DRUG DIS, 2009-05, 5, 467-472. DOI: 10.1517/17460440902916606

Merging microdroplets with laminar flow microfluidics
Abell C, Huck W, Bratton D, Whyte G, Fidalgo L
, 2009, -.

Fragment-based drug discovery in academia: Experiences from a tuberculosis programme
Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield KM, Scott DE, Howard NI, Wen S, Wei AH, Osborne DM, Abell C, Blundell TL
, 2009, 21-36.

Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays.
Courtois F, Olguin LF, Whyte G, Theberge AB, Huck WT, Hollfelder F, Abell C
Anal Chem, 2009, 8, 3008-3016. DOI: 10.1021/ac802658n

Formation of an Organometallic Phosphanediide via Main-Group Dehydrocoupling
Less RJ, Naseri V, Wright DS
ORGANOMETALLICS, 2009, 7, 1995-1997. DOI: 10.1021/om9000296

Total synthesis of (-)-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium cellulosum.
Paterson I, Findlay AD, Noti C
Chem Asian J, 2009, 4, 594-611. DOI: 10.1002/asia.200800445

AuCl3-Catalyzed Hydroalkoxylation of Conjugated Alkynoates: Synthesis of Five- and Six-Membered Cyclic Acetals
Dieguez-Vazquez A, Tzschucke CC, Crecente-Campo J, McGrath S, Ley SV
EUR J ORG CHEM, 2009-04, 11, 1698-1706. DOI: 10.1002/ejoc.200801221

Variant c-type cytochromes as probes of the substrate specificity of the E. coli cytochrome c maturation (Ccm) apparatus
Allen JWA, Sawyer EB, Ginger ML, Barker PD, Ferguson SJ
BIOCHEM J, 2009, 177-184. DOI: 10.1042/BJ20081999

Hydrogen bonding and pi-stacking: how reliable are force fields? A critical evaluation of force field descriptions of nonbonded interactions.
Paton RS, Goodman JM
J Chem Inf Model, 2009-04, 4, 944-955. DOI: 10.1021/ci900009f

Mechanism of BINOL--phosphoric acid-catalyzed strecker reaction of benzyl imines.
Simón L, Goodman JM
J Am Chem Soc, 2009, 11, 4070-4077. DOI: 10.1021/ja808715j

Fluoride-free cross coupling using vinyldisiloxanes.
Sore HF, Boehner CM, MacDonald SJ, Norton D, Fox DJ, Spring DR
Org Biomol Chem, 2009, 6, 1068-1072. DOI: 10.1039/b900852g

A meta-selective copper-catalyzed C-H bond arylation.
Phipps RJ, Gaunt MJ
Science, 2009, 5921, 1593-1597. DOI: 10.1126/science.1169975

Synthetic Studies on Siphonariid Polypropionates: Synthesis and Isomerization of the Caloundrin B Trioxaadamantane Ring System
Beye GE, Goodman JM, Ward DE
ORG LETT, 2009, 6, 1373-1376. DOI: 10.1021/ol900192q

Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
Paterson I, Gardner NM, Guzmán E, Wright AE
Bioorg Med Chem, 2009, 6, 2282-2289. DOI: 10.1016/j.bmc.2008.10.084

A route to enantiomerically pure 5-(2 '-hydroxyethyl)cyclopent-2-en-1-ol and its absolute configuration by Mosher esters
Chen H, Nagabandi S, Smith S, Goodman JM, Plettner E
TETRAHEDRON-ASYMMETR, 2009, 4, 449-456. DOI: 10.1016/j.tetasy.2009.02.007

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays.
Huebner A, Bratton D, Whyte G, Yang M, Demello AJ, Abell C, Hollfelder F
Lab Chip, 2009, 5, 692-698. DOI: 10.1039/b813709a

Recent Advances in Understanding the Mechanism of Cocrystal Formation via Grinding
Friscic T, Jones W
CRYST GROWTH DES, 2009-03, 3, 1621-1637. DOI: 10.1021/cg800764n

Testing the Sensitivity of Terahertz Spectroscopy to Changes in Molecular and Supramolecular Structure: A Study of Structurally Similar Cocrystals
Parrott EPJ, Zeitler JA, Friscic T, Pepper M, Jones W, Day GM, Gladden LF
CRYST GROWTH DES, 2009-03, 3, 1452-1460. DOI: 10.1021/cg8008893

The effect of sodium chloride on poly-l-glutamate conformation.
Fedorov MV, Goodman JM, Schumm S
Chem Commun (Camb), 2009, 8, 896-898. DOI: 10.1039/b816055d

Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis.
Evans AC, Longbottom DA, Matsuoka M, Davies JE, Turner R, Franckevicius V, Ley SV
Org Biomol Chem, 2009, 4, 747-760. DOI: 10.1039/b813494d

Discrete, multi-component complexes with cucurbit[8]uril in the gas-phase.
Deroo S, Rauwald U, Robinson CV, Scherman OA
Chem Commun (Camb), 2009, 6, 644-646. DOI: 10.1039/b818369d

Metal and ligand substitution of the aluminium tris-pyridyl ligands [RAl(2-py')(3)](-) (R = Et, (n)Bu, (s)Bu, (t)Bu; 2-py' = 2-pyridyl, 3-methyl-2-pyridyl, 5-methyl-2-pyridyl, 6-methyl-2-pyridyl).
Bullock TH, Chan WT, Eisler DJ, Streib M, Wright DS
Dalton Trans, 2009, 6, 1046-1054. DOI: 10.1039/b815057e

Deprotection, Tethering, and Activation of a Catalytically Active Metalloporphyrin to a Chemically Active Metal Surface: [SAc](4)P-Mn(III)Cl on Ag(100)
Turner M, Vaughan OPH, Kyriakou G, Watson DJ, Scherer LJ, Davidson GJE, Sanders JKM, Lambert RM
J AM CHEM SOC, 2009, 5, 1910-1914. DOI: 10.1021/ja8076389

What is the mechanism of amine conjugate additions to pyrazole crotonate catalyzed by thiourea catalysts?
Simón L, Goodman JM
Org Biomol Chem, 2009, 3, 483-487. DOI: 10.1039/b817283h

Catalytic electrochemistry of a [NiFeSe]-hydrogenase on TiO2 and demonstration of its suitability for visible-light driven H2 production.
Reisner E, Fontecilla-Camps JC, Armstrong FA
Chem Commun (Camb), 2009, 5, 550-552. DOI: 10.1039/b817371k

Towards quorum-quenching catalytic antibodies.
Kapadnis PB, Hall E, Ramstedt M, Galloway WR, Welch M, Spring DR
Chem Commun (Camb), 2009, 5, 538-540. DOI: 10.1039/b819819e

Toward the total synthesis of the brasilinolides: construction of a differentially protected C20-C38 segment.
Paterson I, Burton PM, Cordier CJ, Housden MP, Mühlthau FA, Loiseleur O
Org Lett, 2009, 3, 693-696. DOI: 10.1021/ol802769e

Evidence for the formation of anhydrous zinc acetate and acetic anhydride during the thermal degradation of zinc hydroxy acetate, Zn-5(OH)(8)(CH3CO2)(2)center dot 4H(2)O to ZnO
Biswick T, Jones W, Pacula A, Serwicka E, Podobinski J
SOLID STATE SCI, 2009-02, 2, 330-335. DOI: 10.1016/j.solidstatesciences.2008.06.018

Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents
Paterson I, Gardner NM, Naylor GJ
PURE AND APPLIED CHEMISTRY, 2009-02, 2, 169-180. DOI: 10.1351/PAC-CON-08-09-17

Toward the total synthesis of the brasilinolides: stereocontrolled assembly of a C1-C19 polyol segment.
Paterson I, Mühlthau FA, Cordier CJ, Housden MP, Burton PM, Loiseleur O
Org Lett, 2009, 2, 353-356. DOI: 10.1021/ol802562b

Gilman-Type versus Lipshutz-Type Reagents: Competition in Lithiocuprate Chemistry
Haywood J, Morey JV, Wheatley AEH, Liu CY, Yasuike S, Kurita J, Uchiyama M, Raithby PR
ORGANOMETALLICS, 2009, 1, 38-41. DOI: 10.1021/om801101u

The crystal structures of three novel lutidinium pamoate salts
Haynes DA, Weng ZF, Jones W, Motherwell WDS
CRYSTENGCOMM, 2009, 2, 254-260. DOI: 10.1039/b814214a

The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome
Friscic T, Childs SL, Rizvi SAA, Jones W
CRYSTENGCOMM, 2009, 3, 418-426. DOI: 10.1039/b815174a

Control and interconversion of cocrystal stoichiometry in grinding: stepwise mechanism for the formation of a hydrogen-bonded cocrystal
Karki S, Friscic T, Jones W
CRYSTENGCOMM, 2009, 3, 470-481. DOI: 10.1039/b812531g

Total synthesis of rapamycin.
Ley SV, Tackett MN, Maddess ML, Anderson JC, Brennan PE, Cappi MW, Heer JP, Helgen C, Kori M, Kouklovsky C, Marsden SP, Norman J, Osborn DP, Palomero MA, Pavey JB, Pinel C, Robinson LA, Schnaubelt J, Scott JS, Spilling CD, Watanabe H, Wesson KE, Willis MC
Chemistry, 2009, 12, 2874-2914. DOI: 10.1002/chem.200801656

Total synthesis of (-)-spirangien a and the corresponding methyl ester
Cranwell PB, Ley SV
Chemtracts, 2009, 5, 173-181.

Enriquez-Garcia A, Ley SV
COLLECT CZECH CHEM C, 2009, 6, 887-900. DOI: 10.1135/cccc2009016

Synthesis of Azadirachtin: A long but successful journey
Veitch GE, Beckmann E, Burke BJ, Boyer A, Maslen SL, Ley SV
Chemtracts, 2009, 6, 214-217.

Second-generation synthesis of azadirachtin: a concise preparation of the propargylic mesylate fragment.
Boyer A, Veitch GE, Beckmann E, Ley SV
Angew Chem Int Ed Engl, 2009, 7, 1317-1320. DOI: 10.1002/anie.200805395

Copper-Catalyzed Arylations of Amines and Alcohols with Boron-Based Arylating Reagents
Thomas AW, Ley SV
Modern Arylation Methods, 2009, 121-154.

An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process
Sedelmeier J, Ley SV, Baxendale IR
GREEN CHEM, 2009, 5, 683-685. DOI: 10.1039/b821752a

Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.
Palmieri A, Ley SV, Polyzos A, Ladlow M, Baxendale IR
Beilstein J Org Chem, 2009, 23-. DOI: 10.3762/bjoc.5.23

The discovery and development of the green fluorescent protein, GFP
Sanders JKM, Jackson SE
Chemical Society Reviews, 2009, 10, 2821-2822.

Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
Redman JE, Granadino-Roldan JM, Schouten JA, Ladame S, Reszka AP, Neidle S, Balasubramanian S
ORG BIOMOL CHEM, 2009, 1, 76-84. DOI: 10.1039/b814682a

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition
Muller S, Pantos GD, Rodriguez R, Balasubramanian S
CHEM COMMUN, 2009, 1, 80-82. DOI: 10.1039/b816861j

Interfacial redox processes of cytochrome b(562)
Zuo P, Albrecht T, Barker PD, Murgida DH, Hildebrandt P
PHYS CHEM CHEM PHYS, 2009, 34, 7430-7436. DOI: 10.1039/b904926f

Supramolecular chemistry: Form leading to function
Scherman OA
Nature Chemistry, 2009, 7, 524-525.

Alumni Profiles
Nitschke JR, Quattropani A, Corminboeuf C, Velonia K, Wilkinson KJ, Kubel F
CHIMIA, 2009, 12, 874-+. DOI: 10.2533/chimia.2009.874

Goodman J
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2009, 12, {2897-2898}-{2897-2898}. DOI: 10.1021/ci900437n

Mechanistic insights into the catalytic asymmetric allylboration of ketones: Brønsted or Lewis acid activation?
Paton RS, Goodman JM, Pellegrinet SC
Org Lett, 2009, 1, 37-40. DOI: 10.1021/ol802270u

Findings of the Challenge To Predict Aqueous Solubility
Hopfinger AJ, Esposito EX, Llinas A, Glen RC, Goodman JM
J CHEM INF MODEL, 2009-01, 1, 1-5. DOI: 10.1021/ci800436c

Joining the crown family; the tetrameric, O-bridged macrocycle [{P(mu-(NBu)-Bu-t)}(2)(mu-O)](4)
Calera SG, Eisler DJ, Goodman JM, McPartlin M, Singh S, Wright DS
DALTON T, 2009, 8, 1293-1296. DOI: 10.1039/b900268p

Joining the crown family; the tetrameric, O-bridged macrocycle [{P(micro-N(t)Bu)}2(micro-O)]4.
Gonzalez Calera S, Eisler DJ, Goodman JM, McPartlin M, Singh S, Wright DS
Dalton Trans, 2009, 8, 1293-1296.

Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water
Au-Yeung HY, Pengo P, Pantos GD, Otto S, Sanders JKM
CHEM COMMUN, 2009, 4, 419-421. DOI: 10.1039/b816979a

Electronic structure and circular dichroism spectroscopy of naphthalenediimide nanotubes
Bulheller BM, Pantoş GD, Sanders JKM, Hirst JD
Physical Chemistry Chemical Physics, 2009, 29, 6060-6065.

Electronic structure and circular dichroism spectroscopy of naphthalenediimide nanotubes
Bulheller BM, Pantos GD, Sanders JKM, Hirst JD
PHYS CHEM CHEM PHYS, 2009, 29, 6060-6065. DOI: 10.1039/b905187b

Crown-ether- and porphyrin-attached gel-phase resins in thermodynamically controlled rotaxane assembly
Mullen KM, Johnstone KD, Nath D, Bampos N, Sanders JKM, Gunter MJ
ORG BIOMOL CHEM, 2009, 2, 293-303. DOI: 10.1039/b816115a

Two-phase dynamic combinatorial discovery of a spermine transporter
Perez-Fernandez R, Pittelkow M, Belenguer AM, Lane LA, Robinson CV, Sanders JKM
CHEM COMMUN, 2009, 25, 3708-3710. DOI: 10.1039/b902842k

Multistep synthesis using modular flow reactors: Bestmann-ohira reagent for the formation of alkynes and triazoles
Baxendale IR, Ley SV, Mansfield AC, Smith CD
Angewandte Chemie - International Edition, 2009, 22, 4017-4021.

The Chemical Synthesis of Discodermolide
Paterson I, Florence GJ
TOP CURR CHEM, 2009, 73-119. DOI: 10.1007/128_2008_7

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents
Paterson I, Findlay AD
AUSTRALIAN JOURNAL OF CHEMISTRY, 2009, 7, 624-638. DOI: 10.1071/CH09104

Dynamic electrochemical investigations of hydrogen oxidation and production by enzymes and implications for future technology.
Armstrong FA, Belsey NA, Cracknell JA, Goldet G, Parkin A, Reisner E, Vincent KA, Wait AF
Chem Soc Rev, 2009-01, 1, 36-51. DOI: 10.1039/b801144n

Structurally Defined Potassium-Mediated Zincation of Pyridine and 4-R-Substituted Pyridines (R = Et, iPr, tBu, Ph, and Me2N) by Using Dialkyl-TMP-Zincate Bases
Clegg W, Conway B, Graham DV, Hevia E, Kennedy AR, Mulvey RE, Russo L, Wright DS
CHEM-EUR J, 2009, 29, 7074-7082. DOI: 10.1002/chem.200900549

Group 2 (Be-Ba) and group 12 (Zn-Hg)
García F, Wright DS
Organometallic Chemistry, 2009, 162-182.

Formation of a new class of 7 pi radicals via sterically induced P-P bond cleavage of the dimers [(CH)(2)(NR)(2)P](2)
Edge R, Less RJ, McInnes EJL, Muther K, Naseri V, Rawson JM, Wright DS
CHEM COMMUN, 2009, 13, 1691-1693. DOI: 10.1039/b821241d

An Introduction to Diversity-Oriented Synthesis
Spandl RJ, Thomas GL, Diaz-Gavilan M, O'Connell KMG, Spring DR
Linker Strategies in Solid-Phase Organic Synthesis, 2009, 239-262.

Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets.
Schaerli Y, Wootton RC, Robinson T, Stein V, Dunsby C, Neil MA, French PM, Demello AJ, Abell C, Hollfelder F
Anal Chem, 2009, 1, 302-306. DOI: 10.1021/ac802038c

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.
Fidalgo LM, Whyte G, Ruotolo BT, Benesch JL, Stengel F, Abell C, Robinson CV, Huck WT
Angew Chem Int Ed Engl, 2009, 20, 3665-3668. DOI: 10.1002/anie.200806103

Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen SJ, Wei AH, Osborne D, Abell C, Blundell TL

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C
Angew Chem Int Ed Engl, 2009, 45, 8452-8456. DOI: 10.1002/anie.200903821

Synthesis of unprecedented scaffold diversity.
Galloway WR, Diáz-Gavilán M, Isidro-Llobet A, Spring DR
Angew Chem Int Ed Engl, 2009, 7, 1194-1196. DOI: 10.1002/anie.200805452

Capillary microreactors wall-coated with mesoporous titania thin film catalyst supports
Rebrov EV, Berenguer-Murcia A, Skelton HE, Johnson BFG, Wheatley AEH, Schouten JC
LAB CHIP, 2009, 4, 503-506. DOI: 10.1039/b815716b

Alkali/coinage metals-organolithium, organocuprate chemistry
Haywood J, Wheatley AEH
Organometallic Chemistry, 2009, 130-161.

Bimetallic PdZn Nanoparticles for the Partial Hydrogenation of Phenylacetylene
Engels V, Wheatley AEH, Berenguer-Murcia A, Jefferson DA, Johnson BFG