Department of Chemistry

Michele Vendruscolo Publications (2010)

Transient tertiary structure formation within the ribosome exit port.
O'Brien EP, Hsu ST, Christodoulou J, Vendruscolo M, Dobson CM
Models, Molecular, Peptide Fragments, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary, Ribosomes 2010, 132, 16928-16937. DOI: 10.1021/ja106530y

Translationally optimal codons associate with aggregation-prone sites in proteins.
Lee Y, Zhou T, Tartaglia GG, Vendruscolo M, Wilke CO
Algorithms, Animals, Codon, Computer Simulation, Escherichia coli Proteins, Halobacterium, Mice, Protein Biosynthesis, Protein Folding, Proteins, Saccharomyces cerevisiae Proteins 2010, 10, 4163-4171. DOI: 10.1002/pmic.201000229

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain.
Gianni S, Ivarsson Y, De Simone A, Travaglini-Allocatelli C, Brunori M, Vendruscolo M
Models, Molecular, Mutation, PDZ Domains, Protein Folding, Protein Structure, Tertiary 2010, 17, 1431-1437. DOI: 10.1038/nsmb.1956

Focus on physical principles of protein behavior in the cell.
Porto M, Roman HE, Vendruscolo M
Animals, Computer Simulation, Genome, Humans, Models, Molecular, Proteins, Proteomics 2010, 10, 4149-4150. DOI: 10.1002/pmic.201090102

Derivation of a solubility condition for proteins from an analysis of the competition between folding and aggregation.
Pechmann S, Vendruscolo M
Escherichia coli, HIV Integrase, Homeostasis, Maltose-Binding Proteins, Models, Biological, Protein Folding, Protein Structure, Quaternary, Proteins, Reproducibility of Results, Solubility, Stochastic Processes 2010, 6, 2490-2497. DOI: 10.1039/C005160H

Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR.
Caporini MA, Bajaj VS, Veshtort M, Fitzpatrick A, MacPhee CE, Vendruscolo M, Dobson CM, Griffin RG
Amyloid, Magnetic Resonance Spectroscopy 2010, 114, 13555-13561. DOI: 10.1021/jp106675h

Proteome-level interplay between folding and aggregation propensities of proteins.
Tartaglia GG, Vendruscolo M
Computational Biology, Escherichia coli, Escherichia coli Proteins, Humans, Protein Binding, Protein Denaturation, Protein Folding, Proteins, Proteome, Proteomics 2010, 402, 919-928. DOI: 10.1016/j.jmb.2010.08.013

Enzymatic activity in disordered states of proteins.
Vendruscolo M
Biocatalysis, Catalytic Domain, Enzymes, Humans, Proteins 2010, 14, 671-675. DOI: 10.1016/j.cbpa.2010.08.022

Using NMR chemical shifts as structural restraints in molecular dynamics simulations of proteins.
Robustelli P, Kohlhoff K, Cavalli A, Vendruscolo M
Models, Molecular, Molecular Dynamics Simulation, Monte Carlo Method, Nuclear Magnetic Resonance, Biomolecular, Protein Folding, Proteins 2010, 18, 923-933. DOI: 10.1016/j.str.2010.04.016

Physicochemical determinants of chaperone requirements.
Tartaglia GG, Dobson CM, Hartl FU, Vendruscolo M
Chaperonin 60, Escherichia coli Proteins, Molecular Chaperones, Protein Folding, Solubility 2010, 400, 579-588. DOI: 10.1016/j.jmb.2010.03.066

The tube model in Gromacs: a platform for the study of protein folding and aggregation
Sandal M, Vendruscolo M
FEBS JOURNAL 2010, 277, 257-257.

An algorithm and experimental protocol to obtain the kinetic parameters of fibrillar growth from a first-principles general model of breakable filament assembly
Cohen SI, Sandal M, Rajah L, Dobson CM, Vendruscolo M, Knowles TPJ
FEBS JOURNAL 2010, 277, 257-257.

Time averaging of NMR chemical shifts in the MLF peptide in the solid state.
De Gortari I, Portella G, Salvatella X, Bajaj VS, van der Wel PC, Yates JR, Segall MD, Pickard CJ, Payne MC, Vendruscolo M
Crystallization, N-Formylmethionine Leucyl-Phenylalanine, Nuclear Magnetic Resonance, Biomolecular, Protein Conformation, Time Factors 2010, 132, 5993-6000. DOI: 10.1021/ja9062629

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide.
Brorsson AC, Bolognesi B, Tartaglia GG, Shammas SL, Favrin G, Watson I, Lomas DA, Chiti F, Vendruscolo M, Dobson CM, Crowther DC, Luheshi LM
Amyloid beta-Peptides, Animals, Drosophila melanogaster, Kinetics, Longevity, Mutant Proteins, Mutation, Neurotoxins, Protein Structure, Quaternary, Thiazoles, Time Factors 2010, 98, 1677-1684. DOI: 10.1016/j.bpj.2009.12.4320

Effects of disease-associated mutations on the aggregation process of the 93-residue N-terminal fragment of human apolipoprotein A-I
Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Relini A, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, Tartaglia GG, Vendruscolo M, Piccoli R, Bellotti V
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 2010, 17, 39-40.

Efficient identification of near-native conformations in ab initio protein structure prediction using structural profiles.
Wolff K, Vendruscolo M, Porto M
Computational Biology, Computer Simulation, Neural Networks (Computer), Protein Conformation, Protein Folding, Proteins 2010, 78, 249-258. DOI: 10.1002/prot.22533