Department of Chemistry

David R Spring Publications (2012)

Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.
Morkunas B, Galloway WR, Wright M, Ibbeson BM, Hodgkinson JT, O'Connell KM, Bartolucci N, Della Valle M, Welch M, Spring DR
Org Biomol Chem 2012, 8452-8464. DOI: 10.1039/C2OB26501J

Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
Tan YS, Sledź P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB
Angew Chem Int Ed Engl 2012, -. DOI: 10.1002/anie.201205676

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
Galloway WR, Hodgkinson JT, Bowden S, Welch M, Spring DR
Trends Microbiol 2012, 449-458. DOI: 10.1016/j.tim.2012.06.003

A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.
O'Connell KM, Beckmann HS, Laraia L, Horsley HT, Bender A, Venkitaraman AR, Spring DR
Org Biomol Chem 2012, 7545-7551. DOI: 10.1039/C2OB26272J

Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa.
Hodgkinson JT, Galloway WR, Wright M, Mati IK, Nicholson RL, Welch M, Spring DR
Org Biomol Chem 2012, 10, 6032-6044. DOI: 10.1039/C2OB25198A

Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.
Frye EC, O' Connor CJ, Twigg DG, Elbert B, Laraia L, Hulcoop DG, Venkitaraman AR, Spring DR
Chemistry 2012, 8774-8779. DOI: 10.1002/chem.201200431

Diversity-oriented synthesis: producing chemical tools for dissecting biology.
O' Connor CJ, Beckmann HS, Spring DR
Chem Soc Rev 2012, 41, 4444-4456. DOI: 10.1039/C2CS35023H

The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.
Lee JW, Carrascón V, Gallimore PJ, Fuller SJ, Björkegren A, Spring DR, Pope FD, Kalberer M
2012, 14, 8023-8031. DOI: 10.1039/C2CP24094G

Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs.
Hodgkinson JT, Galloway WR, Welch M, Spring DR
Nat Protoc 2012, 7, 1184-1192. DOI: 10.1038/nprot.2012.054

Coumarin-derived transformable fluorescent sensor for Zn2+.
Xu Z, Liu X, Pan J, Spring DR
Chem Commun (Camb) 2012, 48, 4764-4766. DOI: 10.1039/C2CC30963G

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.
Zheng S, Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR
Org Biomol Chem 2012, 10, 2590-2593. DOI: 10.1039/C2OB25065A

A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.
Zheng S, Aves SJ, Laraia L, Galloway WR, Pike KG, Wu W, Spring DR
Chemistry 2012, 18, 3193-3198. DOI: 10.1002/chem.201103530

Palladium-catalysed cross-coupling of organosilicon reagents.
Sore HF, Galloway WR, Spring DR
Chem Soc Rev 2012, 41, 1845-1866. DOI: 10.1039/C1CS15181A

Two-directional synthesis as a tool for diversityoriented synthesis: Synthesis of alkaloid scaffolds
O'Connell KMG, Díaz-Gavilán M, Galloway WRJD, Spring DR
Beilstein Journal of Organic Chemistry 2012, 850-860.

Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/ t -Bu solid-phase strategy
Cilibrizzi A, Isidro-Llobet A, Mateu N, Galloway WRJD, Spring DR
Synlett 2012, 0, 290-294.

Synthesis of highly substituted symmetrical 1,3-dienes via organocuprate oxidation
Aves SJ, O'Connell KMG, Pike KG, Spring DR
Synlett 2012, 0, 298-300.

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
Galloway WRJD, Hodgkinson JT, Bowden S, Welch M, Spring DR
Trends in Microbiology 2012, 20, 449-458.

A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives
Zheng S, Aves SJ, Laraia L, Galloway WRJD, Pike KG, Wu W, Spring DR
Chemistry - A European Journal 2012, 3193-3198.

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
Zheng S, Laraia L, O'Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR
Organic and Biomolecular Chemistry 2012, 2590-2593.