Department of Chemistry

David R Spring Publications (2012)


Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.
Morkunas B, Galloway WR, Wright M, Ibbeson BM, Hodgkinson JT, O'Connell KM, Bartolucci N, Della Valle M, Welch M, Spring DR
Org Biomol Chem, 2012, 42, 8452-8464. DOI: 10.1039/C2OB26501J


Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
Tan YS, Śledź P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB
Angew Chem Int Ed Engl, 2012, 40, 10078-10081. DOI: 10.1002/anie.201205676


Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
Tan YS, Sledź P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB
Angew Chem Int Ed Engl, 2012, -. DOI: 10.1002/anie.201205676


A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.
O'Connell KM, Beckmann HS, Laraia L, Horsley HT, Bender A, Venkitaraman AR, Spring DR
Org Biomol Chem, 2012, 37, 7545-7551. DOI: 10.1039/C2OB26272J


Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
Galloway WR, Hodgkinson JT, Bowden S, Welch M, Spring DR
Trends Microbiol, 2012-09, 9, 449-458. DOI: 10.1016/j.tim.2012.06.003


Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.
Frye EC, O'Connor CJ, Twigg DG, Elbert B, Laraia L, Hulcoop DG, Venkitaraman AR, Spring DR
Chemistry, 2012, 28, 8774-8779. DOI: 10.1002/chem.201200431


Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs.
Hodgkinson JT, Galloway WR, Welch M, Spring DR
Nat Protoc, 2012-06, 6, 1184-1192. DOI: 10.1038/nprot.2012.054


The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.
Lee JW, Carrascón V, Gallimore PJ, Fuller SJ, Björkegren A, Spring DR, Pope FD, Kalberer M
Phys Chem Chem Phys, 2012, 22, 8023-8031. DOI: 10.1039/C2CP24094G


Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa.
Hodgkinson JT, Galloway WR, Wright M, Mati IK, Nicholson RL, Welch M, Spring DR
Org Biomol Chem, 2012, 30, 6032-6044. DOI: 10.1039/C2OB25198A


Diversity-oriented synthesis: producing chemical tools for dissecting biology.
O' Connor CJ, Beckmann HS, Spring DR
Chem Soc Rev, 2012, 12, 4444-4456. DOI: 10.1039/C2CS35023H


Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.
Zheng S, Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR
Org Biomol Chem, 2012, 13, 2590-2593. DOI: 10.1039/C2OB25065A


Coumarin-derived transformable fluorescent sensor for Zn2+.
Xu Z, Liu X, Pan J, Spring DR
Chem Commun (Camb), 2012, 39, 4764-4766. DOI: 10.1039/C2CC30963G


Modulating protein-protein interactions with small molecules
O' Connor CJ, Spring DR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, -.


Diversity-oriented synthesis of macrocyclic scaffolds
Beckmann HSG, Spring DR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, -.


Azide-based macrocyclisation strategies towards functionalised stapled peptides
Lau YH, Spring DR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, -.


A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.
Zheng S, Aves SJ, Laraia L, Galloway WR, Pike KG, Wu W, Spring DR
Chemistry, 2012, 11, 3193-3198. DOI: 10.1002/chem.201103530


Synthesis of highly substituted symmetrical 1,3-dienes via organocuprate oxidation
Aves SJ, O'Connell KMG, Pike KG, Spring DR
Synlett, 2012, 2, 298-300.


Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
Galloway WRJD, Hodgkinson JT, Bowden S, Welch M, Spring DR
Trends in Microbiology, 2012, 9, 449-458.


A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives
Zheng S, Aves SJ, Laraia L, Galloway WRJD, Pike KG, Wu W, Spring DR
Chemistry - A European Journal, 2012, 11, 3193-3198.


Two-directional synthesis as a tool for diversityoriented synthesis: Synthesis of alkaloid scaffolds
O'Connell KMG, Díaz-Gavilán M, Galloway WRJD, Spring DR
Beilstein Journal of Organic Chemistry, 2012, 850-860.


Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity
Zheng S, Laraia L, O'Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR
Organic and Biomolecular Chemistry, 2012, 13, 2590-2593.


Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/ t -Bu solid-phase strategy
Cilibrizzi A, Isidro-Llobet A, Mateu N, Galloway WRJD, Spring DR
Synlett, 2012, 2, 290-294.