Department of Chemistry

Peter J Bond Publications (2012)

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP
Animals, Binding Sites, Coumarins, DNA-Binding Proteins, Endoplasmic Reticulum Stress, Endoribonucleases, Humans, Lysine, Membrane Proteins, Mice, Protein Binding, Protein-Serine-Threonine Kinases, Proteolysis, RNA Splicing, RNA, Messenger, Ribonucleases, Schiff Bases, Secretory Pathway, Transcription Factors 2012, 109, E869-E878. DOI: 10.1073/pnas.1115623109

Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms.
Kirchmair J, Williamson MJ, Tyzack JD, Tan L, Bond PJ, Bender A, Glen RC
J Chem Inf Model 2012, 52, 617-648. DOI: 10.1021/ci200542m

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.
Beale TM, Bond PJ, Brenton JD, Charnock-Jones DS, Ley SV, Myers RM
Bioorg Med Chem 2012, 20, 1749-1759. DOI: 10.1016/j.bmc.2012.01.010

Minor pseudopilin self-assembly primes type II secretion pseudopilus elongation
Cisneros DA, Bond PJ, Pugsley AP, Campos M, Francetic O
EMBO Journal 2012, 0, 1041-1053.

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1
Beale TM, Bond PJ, Brenton JD, Charnock-Jones DS, Ley SV, Myers RM
Bioorganic and Medicinal Chemistry 2012, 1749-1759.

A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles
Beale TM, Allwood DM, Bender A, Bond PJ, Brenton JD, Charnock-Jones DS, Ley SV, Myers RM, Shearman JW, Temple J, Unger J, Watts CA, Xian J
ACS Medicinal Chemistry Letters 2012, 177-181.

Computational prediction of metabolism: Sites, products, SAR, P450 enzyme dynamics, and mechanisms
Kirchmair J, Williamson MJ, Tyzack JD, Tan L, Bond PJ, Bender A, Glen RC
Journal of Chemical Information and Modeling 2012, 617-648.