Department of Chemistry

David R Spring Publications (recent)

Functionalised staple linkages for modulating the cellular activity of stapled peptides
Yu Heng Lau, Peterson de Andrade, Soo-Tng Quah, Maxim Rossmann, Luca Laraia, Niklas Skold, Tze Jing Sum, Pamela J E Rowling, Thomas L Joseph, Chandra Verma, Marko Hyvonen, Laura S Itzhaki, Ashok R Venkitaraman, Christopher J Brown, David P Lane, David R Spring
Chemical_Science DOI: 10.1039/C4SC00045E

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis.
Ibbeson BM, Laraia L, Alza E, O' Connor CJ, Tan YS, Davies HM, McKenzie G, Venkitaraman AR, Spring DR
Nat Commun, 2014, 3155-. DOI: 10.1038/ncomms4155

How Diverse Are Diversity Assessment Methods? A Comparative Analysis and Benchmarking of Molecular Descriptor Space.
Koutsoukas A, Paricharak S, Galloway WR, Spring DR, Ijzerman AP, Glen RC, Marcus D, Bender A
J Chem Inf Model, 2013, -. DOI: 10.1021/ci400469u

Concise copper-catalyzed synthesis of tricyclic biaryl ether-linked aza-heterocyclic ring systems.
Mestichelli P, Scott MJ, Galloway WR, Selwyn J, Parker JS, Spring DR
Org Lett, 2013, 21, 5448-5451. DOI: 10.1021/ol4025259

Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing.
Bowden SD, Hale N, Chung JC, Hodgkinson JT, Spring DR, Welch M
Microbiology, 2013-11, Pt 11, 2375-2385. DOI: 10.1099/mic.0.070748-0

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials.
O'Connell KM, Hodgkinson JT, Sore HF, Welch M, Salmond GP, Spring DR
Angew Chem Int Ed Engl, 2013, -. DOI: 10.1002/anie.201209979

" A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling"
Beckmann HSG, Nie F, Hagerman CE, Johansson H, Tan YS, Wilcke D, Spring DR
Nature Chemistry, 2013, 10, 861-867. DOI: 10.1038/nchem.1729

Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp.
Bowden SD, Eyres A, Chung JC, Monson RE, Thompson A, Salmond GP, Spring DR, Welch M
Mol Microbiol, 2013-11, 3, 457-471. DOI: 10.1111/mmi.12369

Ligand binding kinetics of the quorum sensing regulator PqsR.
Welch M, Hodgkinson JT, Gross J, Spring DR, Sams T
Biochemistry, 2013, 25, 4433-4438. DOI: 10.1021/bi400315s

A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells.
Liu T, Xu Z, Spring DR, Cui J
Org Lett, 2013, 9, 2310-2313. DOI: 10.1021/ol400973v