Department of Chemistry

David R Spring Publications (recent)


A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells
Tianyu Liu, Zhaochao Xu, David R Spring, and Jingnan Cui
Organic_Letters DOI: 10.1021/ol400973v


Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections
Postma TM, Galloway WRJD, Cougnon FBL, Pantoş GD, Stokes JE, Spring DR
2013, 765-769.


Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.
Morkunas B, Galloway WR, Wright M, Ibbeson BM, Hodgkinson JT, O'Connell KM, Bartolucci N, Della Valle M, Welch M, Spring DR
Org Biomol Chem 2012, 8452-8464. DOI: 10.1039/C2OB26501J


Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
Tan YS, Sledź P, Lang S, Stubbs CJ, Spring DR, Abell C, Best RB
Angew Chem Int Ed Engl 2012, -. DOI: 10.1002/anie.201205676


Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria.
Galloway WR, Hodgkinson JT, Bowden S, Welch M, Spring DR
Trends Microbiol 2012, 449-458. DOI: 10.1016/j.tim.2012.06.003


A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.
O'Connell KM, Beckmann HS, Laraia L, Horsley HT, Bender A, Venkitaraman AR, Spring DR
Org Biomol Chem 2012, 7545-7551. DOI: 10.1039/C2OB26272J


Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa.
Hodgkinson JT, Galloway WR, Wright M, Mati IK, Nicholson RL, Welch M, Spring DR
Org Biomol Chem 2012, 10, 6032-6044. DOI: 10.1039/C2OB25198A


Palladium-catalysed cross-coupling of vinyldisiloxanes with benzylic and allylic halides and sulfonates.
Frye EC, O' Connor CJ, Twigg DG, Elbert B, Laraia L, Hulcoop DG, Venkitaraman AR, Spring DR
Chemistry 2012, 8774-8779. DOI: 10.1002/chem.201200431


Diversity-oriented synthesis: producing chemical tools for dissecting biology.
O' Connor CJ, Beckmann HS, Spring DR
Chem Soc Rev 2012, 41, 4444-4456. DOI: 10.1039/C2CS35023H


The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.
Lee JW, Carrascón V, Gallimore PJ, Fuller SJ, Björkegren A, Spring DR, Pope FD, Kalberer M
2012, 14, 8023-8031. DOI: 10.1039/C2CP24094G