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Conclusions

Inspired by Corey's suggestion of a hydrogen bond from formyl hydrogens, we modified the transition state force field for the boron-mediated aldol reaction. We conclude:

Acknowledgements

The Royal Society, the EPSRC and the Cambridge Centre for Molecular Recognition are thanked for financial support, and Ian Paterson (Cambridge), Cesare Gennari and Anna Bernardi (Milano) for helpful discussions.
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